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An Exceptionally Selective Lead( II )‐Regulatory Protein from Ralstonia Metallidurans : Development of a Fluorescent Lead( II ) Probe

2005; Wiley; Volume: 44; Issue: 18 Linguagem: Inglês

10.1002/anie.200462443

1521-3773

Peng Chen, Bill Greenberg, Safiyh Taghavi, Christine A. Romano, Daniël van der Lelie, Chuan He,

Drug Transport and Resistance Mechanisms

Lighting up lead: A Pb2+-regulatory protein from Ralstonia metallidurans has been converted into a highly sensitive fluorescent Pb2+ probe (PbR691, turquoise circles in scheme). This fluorescent system reveals that the protein exhibits a surprisingly high binding selectivity towards Pb2+ ions over other metal ions. Supporting Information for this article is available on the WWW under http://www.wiley-vch.de/contents/jc_2002/2005/z462443_s.pdf or from the author. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.