P‐REX2, a novel PI‐3‐kinase sensitive Rac exchange factor
2004; Wiley; Volume: 572; Issue: 1-3 Linguagem: Inglês
10.1016/j.febslet.2004.06.097
ISSN1873-3468
AutoresHans Rosenfeldt, José Vázquez‐Prado, J. Silvio Gutkind,
Tópico(s)Plant nutrient uptake and metabolism
ResumoWe have identified an activator of Rac, P‐REX2, that is structurally related to the exchange factor PtdIns(3,4,5)‐dependent Rac exchanger (P‐REX1), but exhibits distinct tissue‐specific expression. P‐REX2 is spliced into two RNA species, ∼3.5 and ∼10 kb in size. The cDNA corresponding to the smaller transcript encodes a protein that exhibits strong similarity with P‐REX1 within its N‐terminal domains, but differs in the C‐terminal region. P‐REX2 promoted increased levels of GTP‐bound Rac that could be further stimulated by enhancing PI‐3K activity. Thus, P‐REX2 may serve as a novel link between Rac activation and the PI‐3 kinase pathway.
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