Effects of methysergide and naloxone on analgesia induced by the peripheral electric stimulation in mice
1981; Elsevier BV; Volume: 208; Issue: 2 Linguagem: Inglês
10.1016/0006-8993(81)90578-3
ISSN1872-6240
AutoresTakao Shimizu, Takeshi Koja, Tadashi Fujisaki, Takeo Fukuda,
Tópico(s)Neuroscience and Neural Engineering
ResumoWe investigated the antinociceptive effects produced by peripheral electric stimulation (PES) in mice and the influence of administration of l-5-hydroxytryptophan (5-HTP), methysergide and naloxone on the antinociceptive effects of the PES. Administration of 5-HTP enhanced antinociceptive effects induced by PES, while methysergide and naloxone abolished this antinociception. The mechanisms of analgesia produced by PES involve both endogenous opiate systems and central serotonergic mechanisms.
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