Successful treatment of resistant pseudogout with anakinra
2008; Wiley; Volume: 58; Issue: 2 Linguagem: Inglês
10.1002/art.23119
ISSN1529-0131
AutoresDennis McGonagle, Ai Lyn Tan, Julie Madden, Paul Emery, Michael McDermott,
Tópico(s)Gout, Hyperuricemia, Uric Acid
ResumoAbstract We describe herein the case of a 63‐year‐old man with pseudogout affecting multiple joints that was resistant to treatment with allopurinol, steroids, and antiinflammatory drugs. Based on recent data on the molecular mechanism of pseudogout that demonstrated overproduction of interleukin‐1 (IL‐1), we treated the patient with anakinra, an IL‐1 receptor antagonist. The patient responded to treatment with anakinra within 2 weeks, with resolution of the signs and symptoms of pseudogout and normalization of levels of inflammation markers.
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