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Histone H3 lysine-to-methionine mutants as a paradigm to study chromatin signaling

2014; American Association for the Advancement of Science; Volume: 345; Issue: 6200 Linguagem: Inglês

10.1126/science.1255104

1095-9203

Hans-Martin Herz, Marc A. Morgan, Xin Gao, Jessica Jackson, Ryan Rickels, Selene K. Swanson, Laurence Florens, Michael P. Washburn, Joel C. Eissenberg, Ali Shilatifard,

Chromatin Remodeling and Cancer

Chromatin mutations disrupt development Histone proteins form the core packaging material for our genomic DNA, and covalent modifications to amino acid residues in their structure play an important role in the epigenetic control of gene expression. Herz et al. show that specific mutations in the residues that are normally modified to regulate expression cause severe disruption of normal development in the fruit fly. Similar mutations are known to be involved in a subtype of aggressive pediatric brain cancers. Insights into the epigenetic regulatory pathways disrupted by these mutations in Drosophila may suggest possible treatments for human cancers. Science , this issue p. 1065