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Elastic fibre damage induced by low-dose D-penicillamine

1990; Oxford University Press; Volume: 123; Issue: 3 Linguagem: Inglês

10.1111/j.1365-2133.1990.tb06289.x

1365-2133

K. Dalziel, Susan Burge, Peggy Frith, T. J. Ryan, A G Mowat,

Cancer-related Molecular Pathways

We have studied 23 patients receiving penicillamine for the treatment of rheumatoid arthritis to determine the prevalence of penicillamine-induced elastosis. One female patient had pseudoxanthoma elasticum-like skin changes and bramble-bush elastosis without calcification in the involved skin. Penicillamine elastosis was present in the joint capsule in 62% of eight patients or 64% of II joints examined and was detected in joint capsules after as little as I year of treatment.