Conservation of Glutamate Receptor 2-Containing AMPA Receptors during Long-Term Potentiation
2007; Society for Neuroscience; Volume: 27; Issue: 17 Linguagem: Inglês
10.1523/jneurosci.0325-07.2007
ISSN1529-2401
AutoresHillel Adesnik, Roger A. Nicoll,
Tópico(s)Memory and Neural Mechanisms
ResumoLong-term potentiation (LTP) at hippocampal synapses is thought to involve the insertion of AMPA receptors into the postsynaptic membrane. Conflicting evidence exists as to whether calcium-permeable receptors are inserted during LTP and whether synaptic activity mediated by the newly inserted AMPA receptors is required to maintain the increase in synaptic strength. Here, we rigorously test these hypotheses and conclude that calcium-permeable AMPA receptors are not inserted during LTP nor does potentiation require ongoing activity to be maintained.
Referência(s)