Cytotoxic Tirucallane Triterpenoids from Melia azedarach Fruits
2010; Multidisciplinary Digital Publishing Institute; Volume: 15; Issue: 9 Linguagem: Inglês
10.3390/molecules15095866
ISSN1433-1373
AutoresNikoletta Ntalli, Filippo Cottiglia, Carlos Alberto Bueno, Laura E. Alché, Marco Leonti, Simona Vargiu, Ersilia Bifulco, Urania Menkissoglu‐Spiroudi, Pierluigi Caboni,
Tópico(s)Moringa oleifera research and applications
ResumoThe phytochemical investigation of the dichloromethane-soluble part of the methanol extract obtained from the fruits of Melia azedarach afforded one new tirucallane-type triterpene, 3-alpha-tigloylmelianol and three known tirucallanes, melianone, 21-beta-acetoxy-melianone, and methyl kulonate. The structure of the isolated compounds was mainly determined by 1D and 2D NMR experiments as well as HPLC-Q-TOF mass spectrometry. The cytotoxicity of the isolated compounds toward the human lung adenocarcinoma epithelial cell line A549 was determined, while no activity was observed against the phytonematode Meloidogyne incognita.
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