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Amlodipine Treatment of Cocaine Dependence

1999; Taylor & Francis; Volume: 31; Issue: 2 Linguagem: Inglês

10.1080/02791072.1999.10471733

2159-9777

Robert Malcolm, Kathleen T. Brady, Julianne Moore, Daniel K. Kajdasz,

Pharmacological Receptor Mechanisms and Effects

Abstract Preclinical studies indicate that dihydropyridine-type calcium channel antagonists modulate dopamine neurotransmitter function and can reduce cocaine-reinforced behaviors. Amlodipine, a long-acting dihydropyridine-type calcium channel antagonist related to isradipine and nifedipine, was administered in open label fashion for 12 weeks to 26 cocaine-dependent patients. In subjects expressing cocaine craving, craving significantly declined during the course of the 12 weeks. Five individuals reported flushing, headache, fatigue, nocturia, nausea, and lightheadedness. No conclusions regarding efficacy can be made due to the small number of subjects and the openlabel design. Keywords: amlodipinecalcium channel antagonistscocainetreatment