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Impact of Antiretroviral Treatment-Related Toxicities on Hospital Admissions in HIV-Infected Patients

2006; Mary Ann Liebert, Inc.; Volume: 22; Issue: 9 Linguagem: Inglês

10.1089/aid.2006.22.825

1931-8405

Marı́a José Núñez, Luz Martín‐Carbonero, V. Moreno, Eulalia Valencia, Javier García‐Samaniego, Juan González del Castillo, Pablo Barreiro, Juan González‐Lahoz, Vincent Soriano,

HIV/AIDS Research and Interventions

While classical opportunistic infections have decreased as the main cause of hospital admission of HIV-infected patients, other conditions including drug-related toxicities seem to have increased. We assessed the proportion of patients with hospital admission due to antiretroviral (ARV)-related toxicities over the last 7 years at a single HIV/AIDS reference institution located in Madrid. A total of 1981 consecutive hospital admissions in 1581 different HIV-infected patients were analyzed. Nearly half of them (45%) were on ARV therapy. Overall, ARV-related toxicities were the main or secondary reason for hospital admission in 141 patients (7%). Liver toxicity was the most frequent complication (n = 42; 30%), of which one-third were associated with NVP use and 80% occurred in subjects with underlying chronic hepatitis C virus (HCV) infection. Other main ARV-related toxicities were bone marrow toxicity due to zidovudine (17%), pancreatitis (13%), and indinavirassociated nephrolithiasis (6%). Eight patients presented with symptomatic hyperlactatemia, two of them with lactic acidosis. All subjects with ARV-related toxicities had a favorable outcome, except one with prior HCVrelated end-stage liver disease, who died after experiencing hepatic decompensation following initiation of a protease inhibitor-based regimen.