Produção Nacional
MicroRNAs miR-146-5p and let-7f as prognostic tools for aggressive papillary thyroid carcinoma: a case report
2012; Editora da Universidade de São Paulo; Volume: 56; Issue: 8 Linguagem: Inglês
10.1590/s0004-27302012000800015
ISSN1677-9487
AutoresMurilo Vieira Geraldo, César Seigi Fuziwara, Celso Ubirajara Moretto Friguglieti, Ricardo Costa, Marco Aurélio Vamondes Kulcsar, Alex Shimura Yamashita, Edna Teruko Kimura,
Tópico(s)Biomarkers in Disease Mechanisms
ResumoPapillary thyroid cancer (PTC) is the most incident histotype of thyroid cancer. A certain fraction of PTC cases (5%) are irresponsive to conventional treatment, and refractory to radioiodine therapy. The current prognostic factors for aggressiveness are mainly based on tumor size, the presence of lymph node metastasis, extrathyroidal invasion and, more recently, the presence of the BRAFT1799A mutation. MicroRNAs (miRNAs) have been described as promising molecular markers for cancer as their deregulation is observed in a wide range of tumors. Recent studies indicate that the over-expression of miR-146b-5p is associated with aggressiveness and BRAFT1799A mutation. Furthermore, down-regulation of let-7f is observed in several types of tumors, including PTC. In this study, we evaluated the miR146b-5p and let-7f status in a young male patient with aggressive, BRAFT1799A-positive papillary thyroid carcinoma, with extensive lymph node metastases and short-time recurrence. The analysis of miR-146b-5p and let-7f expression revealed a distinct pattern from a cohort of PTC patients, suggesting caution in evaluating miRNA expression data as molecular markers of PTC diagnosis and prognosis.
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