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Dual Effects of Hyperprolactinemia on Carrageenan-Induced Inflammatory Paw Edema in Rats

2011; Karger Publishers; Volume: 18; Issue: 4 Linguagem: Inglês

10.1159/000323774

1423-0216

Julieta E. Ochoa-Amaya, Benjamin Eurico Malucelli, Pablo E. Cruz‐Casallas, Antonia G. Nasello, Luciano Freitas Felício, M.I.R. Carvalho-Freitas,

Stress Responses and Cortisol

The effects of short-term 5-day and long-term 30-day hyperprolactinemia induced by domperidone (1.7 mg/kg/day, s.c.) or ectopic pituitary graft on the acute inflammatory response induced by carrageenan were evaluated in male rats. Both models of hyperprolactinemia effectively increased serum prolactin (PRL) levels.The volume in milliliters of inflammatory edema was measured by plethysmography 1, 2, 3, 4, 6, 8 and 24 h after carrageenan injection. The areas under the inflammatory time-response curves were compared. Additionally, the effects of hyperprolactinemia on body weight and serum corticosterone levels were evaluated.In both domperidone-treated and pituitary graft-implanted animals, short-term 5-day hyperprolactinemia increased the inflammatory response, while long-term 30-day hyperprolactinemia had anti-inflammatory effects. Body weight was not affected by either short- or long-term hyperprolactinemia.These results show that PRL has biphasic effects on the carrageenan-induced inflammatory response.