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The two inverse pathways: the apoptosis and the multinucleated cell switched by the magnesium/zinc balance in irradiated Sarcoma in vivo

1999; Elsevier BV; Volume: 150; Issue: 1-4 Linguagem: Inglês

10.1016/s0168-583x(98)01031-3

1872-9584

Satoshi Harada, K. Sera, S. FUTATSUGAWA, Toru Yanagisawa, Takeo Takahashi, Yoshiharu Tamakawa,

PARP inhibition in cancer therapy

The Mg dependence on apoptosis, and the Zn dependence on the multinucleated cell were evaluated in irradiated Sarcoma-180 in vivo in BALB/c mice. The kinetics of total concentration of Mg strongly correlated with the frequency of apoptosis from 6 to 24 h after irradiation and that of Zn strongly correlated with the frequency of the multinucleated cell from 12 to 48 h after irradiation under the 10 or 20 Gy irradiation. There was an inverse proportion of frequency of apoptosis to that of the multinucleated cell. The administration of Mg significantly increased the frequency of apoptosis and significantly decreased the frequency of the multinucleated cell, from 6 to 12 h after the 20 Gy irradiation. In contrast, the administration of Zn significantly increased the frequency of the multinucleated cell and significantly decreased the frequency of apoptosis from 6 to 12 h under the 20 Gy irradiation. The combined administration of Mg and Zn did not change the frequency of apoptosis and the multinucleated cell. The administration of these elements did not change those correlation coefficients. The two inverse pathways were considered: the one for apoptosis; and another for the multinuclear cell, switched by the Mg/Zn balance.