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Immune regulation by histamine

2002; Elsevier BV; Volume: 14; Issue: 6 Linguagem: Inglês

10.1016/s0952-7915(02)00395-3

1879-0372

Marek Jutel, Takeshi Watanabe, Mübeccel Akdiş, Kurt Blaser, Cezmi A. Akdiş,

Immune Cell Function and Interaction

Histamine is a potent bioamine with multiple activities in various pathological and physiological conditions. In addition to its well-characterised effects in the acute inflammatory and allergic responses, histamine regulates several aspects of antigen-specific immune response development. Histamine affects the maturation of dendritic cells and alters their T cell-polarising capacity. Histamine also regulates antigen-specific T helper 1 and T helper 2 cells, as well as related antibody isotype responses. Apparently, diverse effects of histamine on immune regulation are because of differential expression of four types of histamine receptors and their distinct intracellular signals.