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Screening of Maternal Serum for Fetal Down's Syndrome in the First Trimester

1998; Massachusetts Medical Society; Volume: 338; Issue: 14 Linguagem: Inglês

10.1056/nejm199804023381404

1533-4406

James E. Haddow, Glenn E. Palomaki, George J. Knight, Josephine Williams, Wayne A. Miller, Anthony Johnson,

Parvovirus B19 Infection Studies

Screening of maternal serum to identify fetuses with Down's syndrome is now routinely offered during the second trimester of pregnancy. Prenatal screening by means of serum assays or ultrasonographic measurements, either alone or in combination, may also be possible in the first trimester.