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Dynamic of the Cellular Immune Response at the Dermal Site of Leishmania (L.) amazonensis and Leishmania (V.) braziliensis Infection in Sapajus apella Primate

2014; Hindawi Publishing Corporation; Volume: 2014; Linguagem: Inglês

10.1155/2014/134236

2314-6141

Márcia Dalastra Laurenti, Luiz Felipe Domingues Passero, Thaíse Yumie Tomokane, Fernanda de Camargo Francesquini, Mussya Cisotto Rocha, Cláudia Maria de Castro Gomes, Carlos Eduardo Pereira Corbett, Fernando Tobias Sílveira,

Trypanosoma species research and implications

The purpose of this study was to characterize the immunopathological response in the skin of S. apella infected with Leishmania (L.) amazonensis and L. (V.) braziliensis parasites, the main causative agents of localized cutaneous leishmaniasis in South America. In infected animals, amastigote forms of L. (L.) amazonensis could be detected till 120 days postinfection (PI), while, in L. (V.) braziliensis infection, parasites could be detected until 180 days PI in the skin sections. CD20 + cells were detected throughout the experimental time in both groups as well as in CD3 + cells, which appeared to be activated because high densities of inducible nitric oxide synthase (iNOS + ) cells were detected at 60 and 90 days PI in both studied groups. After 60 and 120 days PI, decrease in iNOS + cells was observed in L. (L.) amazonensis and L. (V.) braziliensis , respectively, which was associated with parasite clearance. Increase in lysozyme + cells was observed during the experimental infections, which also can be associated with parasite killing.