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Hyperosmolal crisis following infusion of hypertonic sodium chloride for purposes of therapeutic abortion

1973; Elsevier BV; Volume: 55; Issue: 1 Linguagem: Inglês

10.1016/0002-9343(73)90158-7

1555-7162

E. Domínguez de Villota, J. M. Cavanilles, Leon Stein, Herbert Shubin, Max Harry Weil,

Potassium and Related Disorders

Transabdominal injection of 250 ml of 23.4 per cent sodium chloride for purposes of inducing abortion during the 18th week of gestation in a 15 year old girl was followed by acute cerebral, cardiac, respiratory and renal failure. Widespread organic damage was attributable to intravascular injection or rapid intravascular absorption of the hypertonic sodium chloride, with consequent expansion of intravascular volume and cellular dehydration. A marked reduction in colloid osmotic pressure was associated with persistent pulmonary edema after reversal of congestive heart failure. A favorable course followed volume repletion, digitalization, administration of corticosteroids, mechanical ventilation and peritoneal dialysis. Except for a minor cerebral deficit that persisted for approximately three months, there was no residual organic impairment.