Portal de Periódicos da CAPES

Comparison of two and ten per cent rectal methohexitone for induction of anaesthesia in children

1988; Springer Science+Business Media; Volume: 35; Issue: 4 Linguagem: Inglês

10.1007/bf03010853

1496-8975

Robert B. Forbes, G. E. Vandewalker,

Anesthesia and Neurotoxicity Research

Plasma methohexitone concentrations were determined in 30 children, aged one to six years, who received 25 mg · kg-1 rectal methohexitone as either a two per cent or ten per cent solution for induction of anaesthesia. Venous blood samples were obtained 15, 30, 45 and 120 minutes following drug administration, Twenty-six of 30 children were asleep within fifteen minutes. Mean plasma methohexitone concentrations were 5.39, 4.42, 3.40 and 1.54 μg·ml-1 at 15, 30, 45 and 120 minutesfollowing administration of two per cent methohexitone. Use of the ten per cent solution resulted in mean plasma methohexitone concentrations of 3.81, 3.12, 2.31 and 1.07 μg · ml-1 at the same time intervals. Plasma methohexitone concentrations were significantly higher at 15, 30 and 45 minutesfollowing administration of two per cent methohexitone, when compared to the ten per cent solution.