Value of SOX10 Immunostaining in Tumor Diagnosis
2013; Lippincott Williams & Wilkins; Volume: 20; Issue: 4 Linguagem: Inglês
10.1097/pap.0b013e318297a9d0
ISSN1533-4031
Autores Tópico(s)Genomics and Chromatin Dynamics
ResumoSOX10 is a transcription factor that is essential for the generation of neural crest cells, their survival, and maintenance of pluripotency. Recent studies have shown that, among tumors, SOX10 is commonly expressed in melanomas, including desmoplastic melanomas, tumors with Schwann cell differentiation, and some salivary gland neoplasms, particularly those with myoepithelial differentiation. Because of its restricted expression, SOX10 has proved to be a useful immunohistochemical marker with a wide range of diagnostic applications in surgical pathology, some of which are briefly reviewed.
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