The purification of large amounts of monoclonal antibodies
1989; Elsevier BV; Volume: 11; Issue: 2-3 Linguagem: Inglês
10.1016/0168-1656(89)90120-x
ISSN1873-4863
Autores Tópico(s)Viral Infectious Diseases and Gene Expression in Insects
ResumoAbstract This article concentrates on the purification of large amounts of monoclonal antibodies. In choosing a purification strategy, the source material and the final application of the end product, as well as the relevant regulatory aspects must be considered. Techniques currently in operation, and aspects to address when bringing a purification strategy into a routine manufacturing environment, such as optimization, scale up and automation are described. Finally, some future driving forces for the large scale purification of monoclonal antibodies are discussed.
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