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Intratubular Germ Cell Neoplasia (ITGCN) with p53 and PCNA Expression and Adjacent Mature Teratoma in an Infant Testis An Immunohistochemical and Morphologic Study with a Review of the Literature

1994; Lippincott Williams & Wilkins; Volume: 18; Issue: 9 Linguagem: Inglês

10.1097/00000478-199409000-00010

1532-0979

David E. Renedo, Thomas D. Trainer,

Testicular diseases and treatments

Intratubular germ cell neoplasia (ITGCN) and mature teratoma of the testis are uncommon findings in children. We report a case of a 3-year-old boy with both ITGCN and mature teratoma—a unique finding in our experience. Immunohistochemical markers, including placental alkaline phosphatase (PLAP), 43–9F, p53, and proliferating cell nuclear antigen (PCNA), as well as the periodic acid-Schiff (PAS) stain, were applied to the ITGCN. PLAP and 43–9F were not detected, whereas p53 and PCNA nuclear expression was detected in ∼5% of atypical germ cells. Abundant clumped intracytoplasmic glycogen deposits were identified within atypical germ cells. Our findings indicate that both PCNA and p53, in addition to a PAS stain, may be useful markers in detecting malignant intratubular germ cells.