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Chemotaxis of sperm cells

2007; National Academy of Sciences; Volume: 104; Issue: 33 Linguagem: Inglês

10.1073/pnas.0703530104

1091-6490

Benjamin M. Friedrich, Frank Jülicher,

Microfluidic and Bio-sensing Technologies

We develop a theoretical description of sperm chemotaxis. Sperm cells of many species are guided to the egg by chemoattractants, a process called chemotaxis. Motor proteins in the flagellum of the sperm generate a regular beat of the flagellum, which propels the sperm in a fluid. In the absence of a chemoattractant, sperm swim in circles in two dimensions and along helical paths in three dimensions. Chemoattractants stimulate a signaling system in the flagellum, which regulates the motors to control sperm swimming. Our theoretical description of sperm chemotaxis in two and three dimensions is based on a generic signaling module that regulates the curvature and torsion of the swimming path. In the presence of a chemoattractant, swimming paths are drifting circles in two dimensions and deformed helices in three dimensions. The swimming paths can be described by a dynamical system that exhibits different dynamic regimes, which correspond to different chemotactic behaviours. We conclude that sampling a concentration field of chemoattractant along circular and helical swimming paths is a robust strategy for chemotaxis that works reliably for a vast range of parameters.