Formation of 1,2,3,4-tetrahydro-β-carboline and methylene-β-phenylethylimine from 5-methyltetrahydrofolate and amines in tissues from developing rat brain
1976; Elsevier BV; Volume: 19; Issue: 4 Linguagem: Inglês
10.1016/0024-3205(76)90227-7
ISSN1879-0631
Autores Tópico(s)Synthesis and bioactivity of alkaloids
ResumoThe rates of synthesis of 1,2,3,4-tetrahydro-β-carboline (THβC) and methylene-β-phenylethylimine (MβΦEI) from 5-methyltetrahydrofolate (5-MTHF) and tryptamine and β-phenylethylamine (βΦEA) respectively have been measured in cerebellum, corpus striatum, and the remainder of the brain from male and female rats at six specific ages after birth. With either substrate the specific activity of the reaction was higher in cerebellum than in corpus striatum until approximately 31 days after birth. The fluctuations in neonatal production of THβC and MβΦEI in cerebellum were nearly parallel except around six days, when THβC production peaked and MβΦEI production dropped considerably. The regional differences in the neonatal patterns of THβC and MβΦEI formation hint that the formaldehyde-forming enzyme (whether or not it is methylane-tetrahydrofolate reductase as we believe) might be related to structural and functional development in specific brain regions.
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