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Extensive cutaneous hyperpigmentation caused by minocycline

1993; Elsevier BV; Volume: 28; Issue: 2 Linguagem: Inglês

10.1016/0190-9622(93)70037-t

1097-6787

Marci Pepine, Franklin P. Flowers, Francisco A. Ramos‐Caro,

Dermatologic Treatments and Research

A 65-year-old man had cutaneous hyperpigmentation that had occurred over the previous 2Vi years. The hyperpigmentation was extensive and involved the sclerae, nail beds, and total body; the palms and buttocks were spared. Clinical diagnosis was suggestive of hemochromatosis or heavy metal deposition. Histologic and electron microscopic findings were consistent with lysosomal iron deposition. A careful history showed that minocycline was the cause. Its use was discontinued, and after several years the patient's pigmentation is gradually returning to normal. A 65-year-old man had cutaneous hyperpigmentation that had occurred over the previous 2Vi years. The hyperpigmentation was extensive and involved the sclerae, nail beds, and total body; the palms and buttocks were spared. Clinical diagnosis was suggestive of hemochromatosis or heavy metal deposition. Histologic and electron microscopic findings were consistent with lysosomal iron deposition. A careful history showed that minocycline was the cause. Its use was discontinued, and after several years the patient's pigmentation is gradually returning to normal.