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Modified shuttle test performance in hospitalized children and adolescents with cystic fibrosis

2006; Elsevier BV; Volume: 5; Issue: 3 Linguagem: Inglês

10.1016/j.jcf.2006.02.004

1873-5010

Narelle S. Cox, Jennifer Follett, Karen McKay,

Asthma and respiratory diseases

BackgroundThe Modified Shuttle Test (MST) is a valid and sensitive measure of exercise capacity in adult CF patients. Recently, its validity in children has been demonstrated. The aim of this study was to demonstrate the utility of the MST as a measure of responsiveness to hospitalisation for i.v. antibiotic and supportive therapy in children and adolescents with CF.Methods28 children and adolescents (40 admissions) performed a MST and lung function within 48 h of admission and discharge to hospital for administration of intravenous antibiotics. Mean age was 12.7 years and antibiotic therapy length was 14.7 days.ResultsUpon admission, the mean (S.D.) FEV1 was 63 (19)% predicted, FVC was 80 (18)% predicted, FEF25–75 43 (29)% predicted and MST distance 718 (232) m. FEV1 increased by 15% (p≤0.001), FVC by 13% (p≤0.001), FEF25–75 by 39% (p≤0.001) and MST distance by 102 m (p≤0.001). The percentage improvement in MST distance at 18% (p≤0.001) was similar to that for FEV1, but could not be predicted by the change in FEV1.ConclusionThis study demonstrated the utility of the MST to assess the effect of hospitalisation for i.v. antibiotic and supportive therapy in children and adolescents with CF.