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Artigo Revisado por pares
BIBTEX RIS

N-Bridged bicyclic sulfonamides as inhibitors of γ-secretase

2009; Elsevier BV; Volume: 19; Issue: 24 Linguagem: Inglês

10.1016/j.bmcl.2009.10.060

ISSN

1464-3405

Autores

Simeon Bowers, Gary D. Probst, Anh P. Truong, Roy K. Hom, Andrei W. Konradi, Hing L. Sham, Albert W. Garofalo, Karina Wong, Erich Goldbach, Kevin P. Quinn, John‐Michael Sauer, William H. Wallace, Lan K. Nguyen, Susanna S. Hemphill, Michael P. Bova, Guriqbal S. Basi,

Tópico(s)

Protein Kinase Regulation and GTPase Signaling

Resumo

The structural modification of a series of [3.3.1] bicyclic sulfonamide based gamma-secretase inhibitors is described. Appropriate substitution on the bicyclic scaffold provides a significant increase in the metabolic stability of the compounds resulting in an improved in vivo metabolic profile.

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