Portal de Periódicos da CAPES

Modulation of reactive oxygen species by antioxidants in chronic myeloid leukemia cells enhances imatinib sensitivity through survivin downregulation

2008; Lippincott Williams & Wilkins; Volume: 19; Issue: 10 Linguagem: Inglês

10.1097/cad.0b013e3283140c6f

1473-5741

Jolie Kiemlian Kwee, Diogo Gomes Luque, Ana Carolina dos Santos Ferreira, Flavia da Cunha Vasconcelos, Karina Lani Silva, Claudete Esteves Klumb, Raquel Ciuvalschi Maia,

Chemotherapy-induced cardiotoxicity and mitigation

Survivin, a member of the inhibitor of apoptosis protein family and a target for new drugs, is modulated by reactive oxygen species in several types of neoplasms including leukemias. The aim of this study is to find mechanisms to enhance sensitivity to imatinib in imatinib-responsive cells. In this study, we demonstrated through fluorescein isothiocyanate-labeled annexin V for apoptotic cells detection and western blotting that by inhibiting catalase activity, imatinib apoptosis induction was significantly enhanced (P<0.05) through diminishing survivin expression in K562 cells. These findings might be of clinical relevance and might help improve the chemotherapeutic use of imatinib mesylate.