EFFECTS OF CATECHOLAMINES, CYCLIC NUCLEOTIDES AND PHOSPHODI-ESTERASE INHIBITORS ON CONTRACTIONS OF SKELETAL MUSCLES IN ANAESTHETIZED CATS
1974; Wiley; Volume: 1; Issue: 4 Linguagem: Inglês
10.1111/j.1440-1681.1974.tb00553.x
ISSN1440-1681
Autores Tópico(s)Neuropeptides and Animal Physiology
ResumoClinical and Experimental Pharmacology and PhysiologyVolume 1, Issue 4 p. 309-323 EFFECTS OF CATECHOLAMINES, CYCLIC NUCLEOTIDES AND PHOSPHODI-ESTERASE INHIBITORS ON CONTRACTIONS OF SKELETAL MUSCLES IN ANAESTHETIZED CATS W. C. Bowman, Corresponding Author W. C. Bowman Department of Physiology and Pharmacology, University of Strathclyde, GlasgowProfessor W. C. Bowman, Department of Physiology and Pharmacology, University of Strathclyde, Glasgow G1 1XW, Scotland.Search for more papers by this authorM. W. Nott, M. W. Nott Department of Physiology and Pharmacology, University of Strathclyde, GlasgowSearch for more papers by this author W. C. Bowman, Corresponding Author W. C. Bowman Department of Physiology and Pharmacology, University of Strathclyde, GlasgowProfessor W. C. Bowman, Department of Physiology and Pharmacology, University of Strathclyde, Glasgow G1 1XW, Scotland.Search for more papers by this authorM. W. Nott, M. W. Nott Department of Physiology and Pharmacology, University of Strathclyde, GlasgowSearch for more papers by this author First published: August 1974 https://doi.org/10.1111/j.1440-1681.1974.tb00553.xCitations: 39AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onEmailFacebookTwitterLinkedInRedditWechat Abstract SUMMARY 1. The actions and interactions of compounds with phosphodiesterase-in-hibiting activity and of sympathomimetic amines have been studied on contractions of skeletal muscles in chloralose-anaesthetized cats treated with bethanidine and in which the adrenals were excluded from the circulation. 2. Compounds with phosphodiesterase-inhibiting activity, ICI 63,197, ICI 58,301, papaverine, theophylline, and dipyridamole, potentiated isoprenaline in its depressant effect on tension and fusion of incomplete tetanic contractions of the slow-contracting soleus muscle, the order of potency being as listed. ICI 63,197 and theophylline also potentiated adrenaline and salbutamol in depressing contractions. 3. ICI 63,197 potentiated isoprenaline in its enhancing effect on tension and degree of fusion of incomplete tetanic contractions of the fast-contracting tibialis anterior and flexor digitorum longus muscles. 4. The results are compatible with the hypothesis that the effects of sympathomimetic amines on muscle contractility are mediated by cyclic adenosine-3',5'-monophosphate, although this nucleotide and its dibutyryl analogue, injected intra-arterially, were themselves without any consistent effect. 5. High doses of ICI 63,197, ICI 58,301, papaverine and dipyridamole, themselves produced isoprenaline-like effects on the soleus muscle. These effects were partially antagonized by (±)-propranolol, (+)-propranolol, or sotalol. The (+)-isomer of propranolol was only about ten times less potent than racemic propranolol in this respect. This antagonistic action of propranolol and sotalol appeared to be independent of β-adrenoceptor blockade. References Bowman, W. C. & Nott, M. W. (1969) Actions of sympathomimetic amines and their antagonists on skeletal muscle. Pharmacological Reviews, 21, 27–72. CASPubMedWeb of Science®Google Scholar Bowman, W. C. & Nott, M. W. 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