HARMFUL LONG-TERM IMPACT OF HEPATITIS C VIRUS INFECTION IN KIDNEY TRANSPLANT RECIPIENTS
1998; Wolters Kluwer; Volume: 65; Issue: 5 Linguagem: Inglês
10.1097/00007890-199803150-00011
ISSN1534-6080
AutoresC. Legendre, Valérie Garrigue, Christine Le Bihan-Benjamin, Marie‐France Mamzer, Marie‐Laure Chaix, Paul Landais, Henri Kreis, S. Pol,
Tópico(s)Liver Disease Diagnosis and Treatment
ResumoBackground. The long-term impact of hepatitis C virus (HCV) infection in renal transplant recipients remains controversial. We report here our experience, in a homogeneous single center, of 499 patients with a fairly long follow-up. Methods. We retrospectively studied 499 hepatitis B virus-negative patients who received an initial cadaver donor kidney transplantation at Necker Hospital between January 1, 1979 and December 31, 1994, with a graft or patient survival of at least 6 months. Anti-HCV antibodies were detected at time of transplantation in 112 patients (22%). Patient survival and causes of death were compared among anti-HCV-positive and -negative patients. Results. Our results clearly indicate that first cadaver kidney transplant recipients with anti-HCV antibodies had a significantly shorter patient and graft long-term survival than recipients without anti-HCV antibodies(P<0.01 and P<0.0001 respectively). Mean follow-up time after transplantation was 79±2 months in the former group and 81±5 months in the latter (NS). Increased mortality was primarily caused by liver disease(P<0.001) and sepsis(P<0.01). In a multivariate analysis, HCV infection significantly affected the mortality rate (odds ratio: 2.8). Conclusions. These results suggest that HCV infection has a harmful long-term impact on the survival of kidney transplant recipients.
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