Regulation of acid production in ketoacidosis and lactic acidosis
1989; Wiley; Volume: 5; Issue: 4 Linguagem: Inglês
10.1002/dmr.5610050406
ISSN1099-0895
AutoresVirginia L. Hood, Richard L. Tannen,
Tópico(s)Diet, Metabolism, and Disease
ResumoDiabetes/Metabolism ReviewsVolume 5, Issue 4 p. 393-409 Article Regulation of acid production in ketoacidosis and lactic acidosis Virginia L. Hood, Virginia L. Hood Department of Medicine, University of Vermont, Burlington, Vermont 05405Search for more papers by this authorRichard L. Tannen, Richard L. Tannen Department of Medicine, University of Southern California, Los Angeles, CaliforniaSearch for more papers by this author Virginia L. Hood, Virginia L. Hood Department of Medicine, University of Vermont, Burlington, Vermont 05405Search for more papers by this authorRichard L. Tannen, Richard L. Tannen Department of Medicine, University of Southern California, Los Angeles, CaliforniaSearch for more papers by this author First published: June 1989 https://doi.org/10.1002/dmr.5610050406Citations: 5AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onEmailFacebookTwitterLinkedInRedditWechat References 1 Hood VL, Danforth E Jr., Horton ES, and Tannen RL: Impact of hydrogen ion on fasting ketogenesis: Feedback regulation of acid production. Am J Physiol 242 (Renal Fluid Electrolyte Physiol 11): F238–F245, 1982. CASPubMedWeb of Science®Google Scholar 2 Hood VL: pH regulation of endogenous acid production in subjects with chronic ketoacidosis. Am J Physiol 249 (Renal Fluid Electrolyte Physiol 18): F220–F226, 1985. CASPubMedWeb of Science®Google Scholar 3 Hood VL, and LaGrange BM: Impact of methionine on net ketoacid production in humans. Metabolism 37: 573–579, 1988. 10.1016/0026-0495(88)90174-6 CASPubMedWeb of Science®Google Scholar 4 Hood VL, and LaGrange BM: pH regulation of ketoacid production contributes to acid-base homeostasis in rats. Clin Res, 406A, 1985. Google Scholar 5 LaGrange BM, and Hood VL: Ketoacid production in acute respiratory and metabolic acidosis and alkalosis in rats. Am J Physiol 256 (Renal Fluid Electrolyte Physiol 25): F437–F445, 1989. CASPubMedWeb of Science®Google Scholar 6 Davies HW, Haldane JBS, and Kennaway EL: Experiments on the regulation of the blood's alkalinity. J Physiol (Lond) 54: 32–45, 1920. 10.1113/jphysiol.1920.sp001906 CASPubMedWeb of Science®Google Scholar 7 Haldane, JBS: Experimental and therapeutic alterations of human tissue alkalinity. Lancet 1: 537–538, 1924. 10.1016/S0140-6736(01)66572-3 Web of Science®Google Scholar 8 Lemann J Jr., Lennon EJ, Goodman D, Litzow JR, and Relman A: The net balance of acid in subjects given large loads of acid or alkali. J Clin Invest 44: 507–517, 1965. 10.1172/JCI105164 CASPubMedWeb of Science®Google Scholar 9 Lemann J Jr., Litzow JR, and Lennon EJ: The effects of chronic acid loads in normal man: further evidence for the participation of base mineral in the defense against chronic metabolic acidosis. J Clin Invest 45: 1608–1614, 1966. 10.1172/JCI105467 CASPubMedWeb of Science®Google Scholar 10 Stinebaugh BJ, Marliss ED, Goldstein MB, Fox IH, Schloeder FX, and Halperin ML: Mechanism for the paradoxical aciduria following alkali administration to prolonged-fasted patients. Metabolism 24: 915–922, 1975. 10.1016/0026-0495(75)90082-7 PubMedWeb of Science®Google Scholar 11 Sapir DG, Chambers NE, and Ryan JW: The role of potassium in the control of ammonium excretion during starvation. Metabolism 25: 211–220, 1976. 10.1016/0026-0495(76)90051-2 CASPubMedWeb of Science®Google Scholar 12 Staubil C: Beitrage zur Pathologie und Therapie des Diabetes Mellitus. Dtsch Arch Klin Med 93: 107–160, 1908. Google Scholar 13 Adlersberg D: Acetonurie und acidose. Biochem Z 143: 527–532, 1923. CASWeb of Science®Google Scholar 14 Lipsky SR, Alper BJ, Rubini ME, Van Eck WF, and Gordon ME: The effects of alkalosis upon ketone body production and carbohydrate metabolism in man. J Clin Invest 33: 1269–1276, 1954. 10.1172/JCI103002 CASPubMedWeb of Science®Google Scholar 15 Mackay EM, Wick AN, Carne HO, and Barnum CP: The influence of alkalosis and acidosis upon fasting ketosis. J Biol Chem 138: 63–68, 1941. CASWeb of Science®Google Scholar 16 Miles JM, Haymond MW, and Gerich JE: Effects of free fatty acids, insulin, glucagon and adrenalin on ketone body production in humans. In Metabolic Acididosis. Pitman Books Ltd, London. CIBA Foundation Symposium 87: 192–213, 1982. Google Scholar 17 Miles JM, Haymond MW, Nissen SL, and Gerich JE: Effects of free fatty acid availability, glucagon excess and insulin deficiency on ketone body production in postabsorptive man. J Clin Invest 71: 1554–1561, 1983. 10.1172/JCI110911 CASPubMedWeb of Science®Google Scholar 18 Fine MB, and Williams RH: Effect of fasting, epinephrine, and glucose and insulin on hepatic uptake of nonesterified fatty acids. Am J Physiol 199: 403–406, 1960. CASPubMedWeb of Science®Google Scholar 19 Basso LV, and Havel RJ: Hepatic metabolism of free fatty acids in normal and diabetic dogs. J Clin Invest 49: 537–547, 1970. 10.1172/JCI106264 CASPubMedGoogle Scholar 20 McGarry JD, Takabayashi Y, and Foster DW: The role of Malonyl-CoA in the coordination of fatty acid synthesis and oxidation in isolated rat hepatocytes. J Biol Chem 253: 8294–8300, 1978. 10.1016/S0021-9258(17)34395-8 CASPubMedWeb of Science®Google Scholar 21 Cook GA, Otto DA, and Cornell NW: Differential inhibition of ketogenesis by malonyl-CoA in mitochondria from fed and starved rats. Biochem J 192: 955–958, 1980. 10.1042/bj1920955 CASPubMedWeb of Science®Google Scholar 22 Ontko JA, and Johns ML: Evaluation of malonyl-CoA in the regulation of long-chain fatty acid oxidation in the liver. Biochem J 192: 959–962, 1980. 10.1042/bj1920959 CASPubMedWeb of Science®Google Scholar 23 Cook GA, Stephens TW, and Harris RA: Altered sensitivity of carnitine palmitoyltransferase to inhibition by malonyl-CoA in ketotic diabetic rats. Biochem J 219: 337–339, 1984. 10.1042/bj2190337 CASPubMedWeb of Science®Google Scholar 24 Williamson JR, Scholz R, and Browning ET: Control mechanisms of gluconeogenesis and ketogenesis. J Biol Chem 244: 4617–4627, 1969. 10.1016/S0021-9258(18)93669-0 CASPubMedWeb of Science®Google Scholar 25 McGarry JD, and Foster DW: The regulation of ketogenesis from octanoic acid, the role of the dicarboxylic acid cycle and fatty acid synthesis. J Biol Chem 246: 1149–1159, 1971. CASPubMedWeb of Science®Google Scholar 26 Scow RO, and Chernick SS: Hormonal control of protein and fat metabolism in the pancreatectomized rat. Recent Progr Hormone Res 16: 497–545, 1960. CASPubMedWeb of Science®Google Scholar 27 Owen OE, Felig P, Morgan AP, Wahren J, and Cahill GF Jr.: Liver and kidney metabolism during prolonged starvation. J Clin Invest 48: 574–583, 1969. 10.1172/JCI106016 CASPubMedWeb of Science®Google Scholar 28 Meier JM, McGarry JD, Faloona GR, Unger RH, and Foster DW: Studies of the development of diabetic ketosis in the rat. J Lipid Res 13: 228–233, 1972. CASPubMedWeb of Science®Google Scholar 29 Zierler KL, and Rabinowitz D: Effects of very small concentrations of insulin on forearm metabolism. Persistence of its action on potassium and free fatty acids without its effect on glucose. J Clin Invest 43: 950–962, 1964. 10.1172/JCI104981 CASPubMedWeb of Science®Google Scholar 30 Bieberdorf FA, Chernick SS, and Scow RO: Effect of insulin and acute diabetes on plasma FFA and ketone bodies in the fasting rat. J Clin Invest 49: 1685–1693, 1970. 10.1172/JCI106386 CASPubMedGoogle Scholar 31 Aguilar-Parada E, Eisentraut AM, and Unger RH: Effect of starvation on plasma pancreatic glucagon in normal man. Diabetes 18: 717–723, 1969. 10.2337/diab.18.11.717 CASPubMedWeb of Science®Google Scholar 32 Miles JM, Rizza RA, Haymond MW, and Gerich JE: Effects of acute insulin deficiency on glucose and ketone body turnover in man. Diabetes 29: 926–930, 1980. 10.2337/diab.29.11.926 CASPubMedWeb of Science®Google Scholar 33 Gerich J, Lorenzi M, Bier D, Isalikian E, Schneider V, Karam J, and Forsham P: Prevention of human diabetic ketoacidosis by somatostatin: Evidence for an essential role of glucagon. N Engl J Med 292: 985–989, 1975. 10.1056/NEJM197505082921901 CASPubMedWeb of Science®Google Scholar 34 Gerich JE, Lorenzi M, Bier DM, Tsalikian E, Schneider V, Karam J, and Forsham P: Effects of Physiological levels of glucagon and growth hormone on human carbohydrate and lipid metabolism. J Clin Invest 57: 875–884, 1976. 10.1172/JCI108364 CASPubMedWeb of Science®Google Scholar 35 McGarry JD, Wright PH, and Foster DW: Hormonal control of ketogenesis, rapid activation of hepatic ketogenic capacity in fed rats by antiinsulin serum and glucagon. J Clin Invest 55: 1202–1209, 1975. 10.1172/JCI108038 CASPubMedWeb of Science®Google Scholar 36 Heimberg M, Weinstein I, and Kohout M: The effects of glucagon, dutyryl cyclic adenosine 3″5′ monophosphate, and concentration of free fatty acid on hepatic lipid metabolism. J Biol Chem 244: 5131–5139, 1969. CASPubMedWeb of Science®Google Scholar 37 Cook GA, Nielsen RC, Hawkins RA, Mehlman MA, Lakshmanan MR, and Veech RL: Effect of glucagon on hepatic malonyl coenzyme a concentration and on lipid synthesis. J Biol Chem 252: 4421–4424, 1977. CASPubMedWeb of Science®Google Scholar 38 McGarry JD, and Foster DW: Regulation of hepatic fatty acid extraction and ketone body production. Ann Rev Biochem 49: 395–420, 1980. 10.1146/annurev.bi.49.070180.002143 CASPubMedWeb of Science®Google Scholar 39 Foster DW, and McGarry JD: The regulation of ketogenesis. In Metabolic Acidosis. CIBA Foundation Symposium 87: 120–131, 1982. Pitman Books Ltd, London. 10.1002/9780470720691.ch7 Web of Science®Google Scholar 40 Demaugre F, Buc H, Girard J, and Leroux JP: Role of the mitochondrial metabolism of pyruvate on the regulation of ketogenesis in rat hepatocytes. Metabolism 32: 40–48, 1982. 10.1016/0026-0495(83)90153-1 Web of Science®Google Scholar 41 Keller U, Oberhansli RD, and Stauffacher W: Adrenergic regulation of ketone body kinetics and lipolysis. In Substrate and Energy Metabolism. John Libbey London, 1985, pp 37–45. Google Scholar 42 Johnston DG, Pernet A, McCulloch A, Blesa-malpiea G, Burrin JM, and Alberti KG: Some hormonal influences on glucose and ketone body metabolism in normal human subjects. In Metabolic Acidosis, CIBA Foundation Symposium 87: 168–191, Pitman Books Ltd, London. Google Scholar 43 Reichard GA, Haff AC, Skutches CL, Paul P, Holroyde CP, and Owen OE: Plasma acetone metabolism in the fasting human. J Clin Invest 63: 619–626, 1979. 10.1172/JCI109344 CASPubMedWeb of Science®Google Scholar 44 Robinson AM, and Williamson DH: Physiological roles of ketone bodies as substrates and signals in mammalian tissues. Physiol Rev 60: 143–187, 1980. 10.1152/physrev.1980.60.1.143 CASPubMedWeb of Science®Google Scholar 45 Keller U, Hood VL, Miles J, and Stauffacher W: Acid base effects on ketone body production and lipolysis in man (abstract). Diabetologica 30: 538A, 1987. Google Scholar 46 Vega FV, and Chiappe GE: Effect of pH on epinephrine-induced libpolysis in isolated fat cells. Am J Physiol 227: 168–170, 1974. CASPubMedWeb of Science®Google Scholar 47 Hjemdahl P, and Fredhold B: Influence of adipose tissue blood flow on the lipolytic response to circulating noradrenaline at normal and reduced pH. Acta Physiol Scand 98: 74–79, 1976. 10.1111/j.1748-1716.1976.tb10304.x CASPubMedWeb of Science®Google Scholar 48 Alberti KG: The hydrogen ion in normal metabolism: A review. In Metabolic Acidosis. CIBA Foundation Symposium 87: 1–19, 1982. Pitman Books Ltd, London. 10.1002/9780470720691.ch1 Web of Science®Google Scholar 49 Nahas GG, and Poyart C: Effect of arterial pH alterations on metabolic activity of norepinephrine. Am J Physiol 212: 765–772, 1967. CASPubMedWeb of Science®Google Scholar 50 Jones NO, Sutton JR, Taylor R, and Toews CJ: Effect of pH on cardiorespiratory and metabolic response to exercise. J Appl Physiol: Respirat Environ Exercise Physiol 43: 959–964, 1977. CASPubMedWeb of Science®Google Scholar 51 Ehrsam RE, Heigenhauser GJ, and Jones NL: Effect of respiratory acidosis on metabolism in exercise. J Appl Physiol Respirat Environ Exercise Physiol 53: 63–69, 1982. 10.1152/jappl.1982.53.1.63 CASPubMedWeb of Science®Google Scholar 52 Farfournoux P, Demigne C, and Remsey C: Mechanisms involved in ketone body release by rat liver cells: Influence of pH and bicarbonate. Am J Physiol 252: G200–G208, 1987. PubMedWeb of Science®Google Scholar 53 Stephens, TW, Cook G, and Harris R: Effect of pH on malonyl CoA inhibition of carnitine palmitoyltransferase I. Biochem J 212: 521–524, 1983. 10.1042/bj2120521 CASPubMedWeb of Science®Google Scholar 54 McGarry, Dennis J, Leatherman GF, and Foster DW: Carnitine palymitoyltransferase I, the site inhibition of hepatic fatty acid oxidation by malonyl-coA. J Biol Chem 253: 4128–4136, 1978. CASPubMedWeb of Science®Google Scholar 55 Metcalfe, HK, Monson JP, Welch SG, and Cohen RD: Carrier-mediated efflux of ketone bodies in isolated rat hepatocytes. Clin Sci 71: 755–761, 1986. CASPubMedWeb of Science®Google Scholar 56 Fery F, and Balasse E: Differential effects of sodium acetoacetate and acetoacetate acid infusions on alanine and glutamine metabolism in man. J Clin Invest 66: 323–331, 1980. 10.1172/JCI109860 CASPubMedWeb of Science®Google Scholar 57 Angielski S, and Lukowicz J: The role of the kidney in the removal of ketone bodies under different acid-base status of the rat. Am J Clin Nutr 31: 1635–1641, 1978. CASPubMedWeb of Science®Google Scholar 58 Lemieux G, Achkar M, Vinay P, and Gougoux A: The effect of acid-base status on renal utilization of ketone bodies. In vitro studies in the rat. Proceedings of the 8th International Congress of Nephrology, S. Karger, Basel, 1981, pp 834–840. Google Scholar 59 Goldstein L: Renal substrate utilization in normal and acidotic rats. Am J Physiol 253: F351–F357, 1987. CASPubMedWeb of Science®Google Scholar 60 Gevers W, and Dowdle E: The effect of pH on glycolysis in vitro. Clin Sci 25: 343–349, 1963. CASPubMedWeb of Science®Google Scholar 61 Ui M, Glende EA Jr., and Cornatzer WE: The phospholipid fatty acid composition of liver, kidney, heart and spleen mitochondria from rats of various age groups. Biochim Biophys Acta 124: 310–318, 1966. 10.1016/0304-4165(66)90194-2 CASPubMedWeb of Science®Google Scholar 62 Scheuer J, and Berry MN: Effect of alkalosis on glycolysis in the isolated rat heart. Am J Physiol 213: 1143–1148, 1967. CASPubMedWeb of Science®Google Scholar 63 Albrecht V, Roigas H, Schultze M, Jacobasch G, and Rapoport S: The influence of pH and methylene blue on the pathways of glucose utilization and lactate formation in erythrocytes of man. Eur J Biochem 20: 44–50, 1971. 10.1111/j.1432-1033.1971.tb01360.x CASPubMedWeb of Science®Google Scholar 64 Minakami S, Saito T, Suzuki C, and Yoshikawa H: The hydrogen ion concentrations and erythrocyte glycolysis. Biochem Biophys Res Comm 17: 748–751, 1964. 10.1016/0006-291X(64)90425-5 CASWeb of Science®Google Scholar 65 Halperin M, Connors H, Relman A, and Karnovsky M: Factors that control the effect of pH on glycolysis in leukocytes. J Biol Chem 244: 384–390, 1969. 10.1016/S0021-9258(18)94442-X CASPubMedWeb of Science®Google Scholar 66 Relman AS: Metabolic consequences of acid-base disorders. Kidney Int 1: 347–359, 1972. 10.1038/ki.1972.46 CASPubMedWeb of Science®Google Scholar 67 Goldstein P, Simmons D, and Tashkin D: Effect of acid-base alterations on hepatic lactate utilization. J Physiol 223: 261–278, 1972. 10.1113/jphysiol.1972.sp009846 CASPubMedWeb of Science®Google Scholar 68 Leal-Pinto E, Park H, King F, MacLeod M, and Pitts R: Metabolism of lactate by the intact functioning kidney of the dog. Am J Physiol 224: 1463–1467, 1973. CASPubMedWeb of Science®Google Scholar 69 Zborowska-Sluis DT, and Dossetor JB: Hyperlactatemia of hyperventilation. J Appl Physiol 22: 746–755, 1967. 10.1152/jappl.1967.22.4.746 CASPubMedWeb of Science®Google Scholar 70 Huckabee WE: Relationships of pyruvate and lactate during anaerobic metabolism. I. Effects of infusion of pyruvate or glucose and of hyperventilation. J Clin Invest 37: 244–254, 1958. 10.1172/JCI103603 CASPubMedWeb of Science®Google Scholar 71 Eichenholz A, Mulhausen RO, Anderson W, and MacDonald F: Primary hypocapnia: A cause of metabolic acidosis. J Appl Physiol 17: 283–288, 1962. CASPubMedWeb of Science®Google Scholar 72 Ellison R, McPherson J Jr., Parish G, and Ellison L: Hypoxia, respiratory alkalosis and acidosis in development of metabolic acidosis (abstract). Clin Res 13: 74, 1965. Google Scholar 73 Cain S, and Dunn JE: Transient arterial lactic acid changes in unanesthetized dogs at 21,000 feet. Am J Physiol 206: 1437–1440, 1964. CASPubMedWeb of Science®Google Scholar 74 Yajima M, and Ui M: Hydrocortisone restoration of the pH-dependent metabolic responses to catecholamines. Am J Physiol 228: 1053–1059, 1975. CASPubMedWeb of Science®Google Scholar 75 Giebisch G, Berger L, and Pitts RF: The extrarenal response to acute acid base disturbances of respiratory origin. J Clin Invest 34: 231–245, 1955. 10.1172/JCI103076 CASPubMedWeb of Science®Google Scholar 76 Tobin RB, and Mehlan MA: pH effects on O2 consumption and on lactate and pyruvate production by liver slices. Am J Physiol 221: 1151–1155, 1971. CASPubMedWeb of Science®Google Scholar 77 Berry M, and Scheuer J: Splanchnic lactic acid metabolism in hyperventilation, metabolic alkalosis and shock. Metabolism 16: 537–574, 1967. 10.1016/0026-0495(67)90084-4 CASPubMedWeb of Science®Google Scholar 78 Eldridge F, and Salzer J: Effect of respiratory alkalosis on blood lactate in humans. J Appl Physiol 22: 461–468, 1967. CASPubMedWeb of Science®Google Scholar 79 Engel K, Hildeberg PA, Fine BP, and Winters RW: Effects of acute respiratory acidosis on blood lactate concentration. Scand J Clin Lab Invest 20: 179–182, 1967. 10.3109/00365516709076940 Web of Science®Google Scholar 80 Oliva PB: Lactic acidosis. Am J Med 48: 209–225, 1970. 10.1016/0002-9343(70)90117-8 CASPubMedWeb of Science®Google Scholar 81 Gennari FJ, Goldstein MB, and Schwartz WB: Nature of renal adaptation to chronic hypocapnia. J Clin Invest 51: 1722–1730, 1972. 10.1172/JCI106973 CASPubMedWeb of Science®Google Scholar 82 Arieff AI, and Kerian A: Lactic acidosis: An experimental model. Metabolism 25: 307–312, 1976. 10.1016/0026-0495(76)90088-3 CASWeb of Science®Google Scholar 83 Arieff AI, Leach WJ, and Lazarowitz VC: Effects of NaHCO3 in therapy of experimental lactic acidosis. Kidney Int 14: 645, 1978. Web of Science®Google Scholar 84 Arieff AI, Park R, Leach WJ, and Lazarowtiz VC: Pathophysiology of experimental lactic acidosis in dogs. Am J Physiol 239F: 135–142, 1980. Google Scholar 85 Leach WJ, and Arieff AI: Systemic effects of bicarbonate in experimental lactic acidosis in diabetic rabbits. Clin Res 29: 411A, 1981. Google Scholar 86 Fraley DS, Adler S, Bruns FJ, and Zett B: Stimulation of lactate production by administration of bicarbonate in a patient with a solid neoplasm and lactic acidosis. N Engl J Med 303: 1100–1102, 1980. 10.1056/NEJM198011063031907 CASPubMedWeb of Science®Google Scholar 87 Fields ALA, Wolman SL, and Halperin ML: Chronic lactic acidosis in a patient with cancer: Therapy and metabolic consequences. Cancer 47: 2026–2029, 1981. 10.1002/1097-0142(19810415)47:8 3.0.CO;2-G CASPubMedWeb of Science®Google Scholar 88 Graf H, Leach W, and Arieff AI: Metabolic effects of sodium bicarbonate in hypoxic lactic acidosis in dogs. Am J Physiol 249 (Renal Fluid Electrolyte Physiol 18): F630–F635, 1985. CASPubMedWeb of Science®Google Scholar 89 Graff H, Leach W, and Arieff AI: Evidence for a detrimental effect of bicarbonate therapy in hypoxic lactic acidosis. Science 227: 754–756, 1985. 10.1126/science.3969564 PubMedWeb of Science®Google Scholar 90 Abu Romeh S, and Tannen RL: Amelioration of hypoxia-induced lactic acidosis by superimposed hypercapnea or hydrochloric acid infusion. Am J Physiol 250: F702–F709, 1986. CASPubMedWeb of Science®Google Scholar 91 Seo Y: Effects of extracellular pH on lactate efflux from frog sartorius muscle. Am J Physiol 247 (Cell Physiol 16): C175–C181, 1984. 10.1152/ajpcell.1984.247.3.C175 CASPubMedWeb of Science®Google Scholar 92 Spriet LL, Lindinger MI, Heigenhauser GJF, and Jones NL: Effects of alkalosis on skeletal muscle metabolism and performance during exercise. Am J Physiol 251 (Regul Integr Comp Physiol 20): R833–R839, 1986. CASPubMedWeb of Science®Google Scholar 93 Sutton JR, Jones NL, and Toews CJ: Effect of pH on muscle glycolysis during exercise. Clin Sci 61: 331–338, 1981. 10.1042/cs0610331 CASPubMedWeb of Science®Google Scholar 94 Jennings ML, and Adams-Lackey M: A rabbit erythrocyte membrane protein associated with L-Lactate transport. J Biol Chem 257: 12866–12871, 1982. CASPubMedWeb of Science®Google Scholar 95 Graham TE, Barclay JK, and Wilson BA: Skeletal muscle lactate release and glycolytic intermediates during hypercapnia. J Appl Physiol 60 (2): 568–575, 1986. CASPubMedWeb of Science®Google Scholar 96 Park R, and Arieff AI: Lactic acidosis. Adv Intern Med 25: 33–68, 1980. CASPubMedGoogle Scholar 97 Kreisberg RA: Lactate homeostasis and lactic acidosis. Ann Intern Med 92: 227–237, 1980. 10.7326/0003-4819-92-2-227 CASPubMedWeb of Science®Google Scholar 98 Arieff AI, and Graf H: Pathophysiology of type A hypoxic lactic acidosis in dogs. Am J Physiol 253 (Endocrinol Metab 16): E271–E276, 1987. 10.1152/ajpendo.1987.253.3.E271 CASPubMedWeb of Science®Google Scholar 99 Trivedi B, and Danforth WH: Effect of pH on the kinetics of frog muscle phosphofruetokinase. J Biol Chem 241: 4110–4114, 1966. CASPubMedWeb of Science®Google Scholar 100 Carpenter JF, and Hand SC: Reversible dissociation and inactivation of phosphofructokinase in the ischemic rat heart. Am J Physiol 250 (Regul Integr Comp Physiol 19): R512–R518, 1986. CASPubMedWeb of Science®Google Scholar 101 Hand SC, and Carpenter JF: pH-induced hysteretic properties of phosphofruetokinase purified from rat myocardium. Am J Physiol 250 (Regul Integr Comp Physiol 19): R505–R511, 1986. CASPubMedWeb of Science®Google Scholar 102 Dobson GP, Yamamoto E, and Hochachka PW: Phosphofructokinase control in muscle: Nature and reversal of pH-dependent ATP inhibition. Am J Physiol 250 (Regul Integr Comp Physiol 19): R71–R76, 1986. 10.1152/ajpregu.1986.250.1.R71 CASPubMedWeb of Science®Google Scholar 103 Hue L, and Rider MH: Role of fructose 2,6-bisphosphate in the control of glycolysis in mammalian tissues. Biochem J 245: 313–324, 1987. 10.1042/bj2450313 CASPubMedWeb of Science®Google Scholar 104 Sutton JR, Jones NL, and Toews CJ: Effect of pH on muscle glycolysis during exercise. Clin Sci 61: 331–338, 1981. 10.1042/cs0610331 CASPubMedWeb of Science®Google Scholar 105 Hirche H, Hombach V, Langohr HD, Wacker V, and Busse J: Lactic acid permeation rate in working gastronemii of dogs during metabolic alkalosis and acidosis. Pflügers Arch 356: 209–222, 1975. 10.1007/BF00583833 CASPubMedWeb of Science®Google Scholar 106 Spriet LL, Matsos CG, Peters SJ, Heigenhauser GJF, and Jones NL: Effects of acidosis on rat muscle metabolism and performance during heavy exercise. Am J Physiol 248 (Cell Physiol 17): C337–C347, 1985. 10.1152/ajpcell.1985.248.3.C337 CASPubMedWeb of Science®Google Scholar 107 Hood VL, Schubert C, Keller V, and Muller S: Effect of systemic pH on pHi and lactic acid generation in exhaustive forearm exercise. Am J Physiol 255 (Renal Fluid Electrolyte Physiol 24): F479–F485, 1988. 10.1152/ajpcell.1988.255.4.C479 CASPubMedWeb of Science®Google Scholar 108 Kowalchuk JM, Heigenhauser GJF, and Jones NL: Effect of pH on metabolic and cardiorespiratory responses during progressive exercise. J Appl Physiol (Respirat Environ Exercise Physiol) 57: 1588–1563, 1984. Google Scholar 109 Hems R, Ross BD, Berry MN, and Krebs HA: Glyconeogenesis in the perfused rat liver. Biochem J 101: 384–292, 1966. Google Scholar 110 Iles RA, Cohen RD, Rist RH, and Baron PG: The mechanism of inhibition by acidosis of gluconeogenesis from lactate in rat liver. Biochem J 164: 185–191, 1977. 10.1042/bj1640185 CASPubMedWeb of Science®Google Scholar 111 Lloyd MH, Iles RA, Simpson BR, Strunin JM, Layton JM, and Cohen RD: The effect of simulated metabolic acidosis on intracellular pH and lactate metabolism in isolated perfused rat liver. Clin Sci Mol Med 45: 543–549, 1973. CASPubMedWeb of Science®Google Scholar 112 Baron PG, Iles RA, and Cohen RD: Effect of varying PCO2 on intracellular pH and lactate consumption in the isolated perfused rat liver. Clin Sci 55: 175–181, 1978. CASPubMedWeb of Science®Google Scholar 113 Seglen PO: The effect of perfusate pH on respiration and glycolysis in the isolated rat liver perfused with an erythrocyte and protein free medium. Biochim Biophys Acta 264: 398–410, 1972. 10.1016/0304-4165(72)90002-5 CASPubMedWeb of Science®Google Scholar 114 Sestoft L, Marshall MO: Hepatic lactate uptake is enhanced by low pH at low lactate concentrations in perfused rat liver. Clin Sci 70: 19–22, 1986. CASPubMedWeb of Science®Google Scholar 115 Yudkin J, and Cohen RD: Contribution of kidney to removal of a lactic-acid load under normal and acidotic conditions in conscious rat. Clin Sci Mol 48: 121–131, 1975. CASPubMedWeb of Science®Google Scholar 116 Naylor JM, Kronfeld DS, Freeman DE, and Richardson D: Hepatic and extrahepatic lactate metabolism in sheep: Effects of lactate loading and pH. Am J Physiol 247 (Endocrinol Metab 10): E747–E755, 1984. 10.1152/ajpendo.1984.247.6.E747 CASPubMedWeb of Science®Google Scholar 117 Alleyne GAO, Flores H, and Roobol A: The interrelationship of the concentration of hydrogen ions, bicarbonate ions, carbon dioxide and calcium ions in the regulation of renal gluconeogenesis in the rat. Biochem J 136: 445–453, 1973. CASPubMedWeb of Science®Google Scholar 118 Dawson AG: Contribution of pH sensitive metabolic processes to pH homeostasis in isolated rat kidney tubules. Biochim Biophys Acta 499: 85–98, 1977. 10.1016/0304-4165(77)90231-8 CASPubMedWeb of Science®Google Scholar 119 Pahsley DH, and Cohen JJ: Substrate interconversion in dog kidney cortex slices: Regulation of ECF-pH. Am J Physiol 225: 1519–1528, 1973. PubMedWeb of Science®Google Scholar 120 Yudkin J, and Cohen JD: Effect of acidosis on lactate removal by perfused rat kidney. Clin Sci 50: 185–194, 1976. CASPubMedWeb of Science®Google Scholar 121 Hannaford MC, Leiten LA, Josse RG, Goldstein MB, Marliss EB, and Halperin ML: Protein wasting due to acidosis of prolonged fasting. Am J Physiol 243: E251–E256, 1982. CASPubMedWeb of Science®Google Scholar 122 Hale PJ, Crase J, and Nattrass M: Metabolic effects of bicarbonate in the treatment of diabetic ketoacidosis. Brit Med J 289: 1035–1038, 1984. 10.1136/bmj.289.6451.1035 CASPubMedWeb of Science®Google Scholar 123 Neary RH, and Edwards JD: Metabolic alkalosis and hyperlactataemia. Brit Med J 294: 1462, 1987. 10.1136/bmj.294.6585.1462 CASPubMedWeb of Science®Google Scholar 124 Yajima M, and Ui M: Carbohydrate metabolism and its response to catecholamines as modified in alkalotic rat. Am J Physiol 228: 1046–1052, 1975. CASPubMedWeb of Science®Google Scholar 125 Chiesa A, Stretton T, Massoud A, and Howell J: The effects of inhibition of carbonic anhydrase with dichlorphenamide on ventilatory control at rest and on exercise in normal subjects. Clin Sci 37: 689–706, 1969. CASPubMedWeb of Science®Google Scholar Citing Literature Volume5, Issue4June 1989Pages 393-409 ReferencesRelatedInformation
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