Synthesis of side-chain functionalized amino acid derivatives through reaction of alkyl nitronates with α-bromoglycine derivatives
1995; Elsevier BV; Volume: 51; Issue: 28 Linguagem: Inglês
10.1016/0040-4020(95)00398-r
ISSN1464-5416
AutoresChristopher J. Easton, Peter Roselt, Edward R. T. Tiekink,
Tópico(s)Synthesis and Catalytic Reactions
ResumoReactions of alkyl nitronates with α-bromoglycine derivatives provide access to a variety of halo-, β-nitroand α,β-dehydro-α-amino acid derivatives, including β-functionalized α,β-dehydroamino acid derivatives. The hydrochloride salts of free β-nitro-α-amino acids can also be prepared using this approach.
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