Produção Nacional
Revisado por pares
Prevalence of autoimmune thyroid disease and thyroid dysfunction in young Brazilian patients with type 1 diabetes
2008; Wiley; Volume: 9; Issue: 4pt1 Linguagem: Inglês
10.1111/j.1399-5448.2008.00394.x
ISSN1399-5448
AutoresJacqueline Araújo, Lucas AC Brandão, Rafael Lima Guimarães, Sérgio Santos, Elcy A. Falcão, Michele Milanese, Ludovica Segat, Paulo Roberto Eleutério de Souza, José Luiz de Lima-Filho, Sérgio Crovella,
Tópico(s)Pancreatic function and diabetes
ResumoPediatric DiabetesVolume 9, Issue 4pt1 p. 272-276 Prevalence of autoimmune thyroid disease and thyroid dysfunction in young Brazilian patients with type 1 diabetes Jacqueline Araujo, Corresponding Author Jacqueline Araujo Pediatric Endocrinology Unit of Clinical Hospital, Federal University of Pernambuco, Recife, Pernambuco, Brazil Maternal and Children Institute of Pernambuco, Recife, Pernambuco, BrazilJacqueline AraujoRua Dhália, No 304, Apartment 902Boa ViagemRecifePernambuco 51020-290Brazil.Tel: +55 81 34451145;fax: 55 81 34451145;e-mail: jacqueline.araujo@gmail.comSearch for more papers by this authorLucas AC Brandão, Lucas AC Brandão Laboratory of Immunopathology Keizo Asami, Federal University of Pernambuco, Recife, Pernambuco, BrazilSearch for more papers by this authorRafael L Guimarães, Rafael L Guimarães Laboratory of Immunopathology Keizo Asami, Federal University of Pernambuco, Recife, Pernambuco, BrazilSearch for more papers by this authorSérgio Santos, Sérgio Santos Department of Cellular Biology and Ultrastructure, Aggeu Magalhaes Research Center – CPqAM/FIOCRUZ, Recife, Pernambuco, BrazilSearch for more papers by this authorElcy A Falcão, Elcy A Falcão Restoration Hospital, Recife, Pernambuco, BrazilSearch for more papers by this authorMichele Milanese, Michele Milanese Genetics Service, IRCCS Burlo Garofolo and Department of Reproductive and Developmental Sciences, University of Trieste, ItalySearch for more papers by this authorLudovica Segat, Ludovica Segat Genetics Service, IRCCS Burlo Garofolo and Department of Reproductive and Developmental Sciences, University of Trieste, ItalySearch for more papers by this authorPaulo R Souza, Paulo R Souza Laboratory of Immunopathology Keizo Asami, Federal University of Pernambuco, Recife, Pernambuco, BrazilSearch for more papers by this authorJosé Luiz De Lima-Filho, José Luiz De Lima-Filho Laboratory of Immunopathology Keizo Asami, Federal University of Pernambuco, Recife, Pernambuco, BrazilSearch for more papers by this authorSergio Crovella, Sergio Crovella Genetics Service, IRCCS Burlo Garofolo and Department of Reproductive and Developmental Sciences, University of Trieste, Italy Department of Genetics, Federal University of Pernambuco, Recife, Pernambuco, BrazilSearch for more papers by this author Jacqueline Araujo, Corresponding Author Jacqueline Araujo Pediatric Endocrinology Unit of Clinical Hospital, Federal University of Pernambuco, Recife, Pernambuco, Brazil Maternal and Children Institute of Pernambuco, Recife, Pernambuco, BrazilJacqueline AraujoRua Dhália, No 304, Apartment 902Boa ViagemRecifePernambuco 51020-290Brazil.Tel: +55 81 34451145;fax: 55 81 34451145;e-mail: jacqueline.araujo@gmail.comSearch for more papers by this authorLucas AC Brandão, Lucas AC Brandão Laboratory of Immunopathology Keizo Asami, Federal University of Pernambuco, Recife, Pernambuco, BrazilSearch for more papers by this authorRafael L Guimarães, Rafael L Guimarães Laboratory of Immunopathology Keizo Asami, Federal University of Pernambuco, Recife, Pernambuco, BrazilSearch for more papers by this authorSérgio Santos, Sérgio Santos Department of Cellular Biology and Ultrastructure, Aggeu Magalhaes Research Center – CPqAM/FIOCRUZ, Recife, Pernambuco, BrazilSearch for more papers by this authorElcy A Falcão, Elcy A Falcão Restoration Hospital, Recife, Pernambuco, BrazilSearch for more papers by this authorMichele Milanese, Michele Milanese Genetics Service, IRCCS Burlo Garofolo and Department of Reproductive and Developmental Sciences, University of Trieste, ItalySearch for more papers by this authorLudovica Segat, Ludovica Segat Genetics Service, IRCCS Burlo Garofolo and Department of Reproductive and Developmental Sciences, University of Trieste, ItalySearch for more papers by this authorPaulo R Souza, Paulo R Souza Laboratory of Immunopathology Keizo Asami, Federal University of Pernambuco, Recife, Pernambuco, BrazilSearch for more papers by this authorJosé Luiz De Lima-Filho, José Luiz De Lima-Filho Laboratory of Immunopathology Keizo Asami, Federal University of Pernambuco, Recife, Pernambuco, BrazilSearch for more papers by this authorSergio Crovella, Sergio Crovella Genetics Service, IRCCS Burlo Garofolo and Department of Reproductive and Developmental Sciences, University of Trieste, Italy Department of Genetics, Federal University of Pernambuco, Recife, Pernambuco, BrazilSearch for more papers by this author First published: 28 July 2008 https://doi.org/10.1111/j.1399-5448.2008.00394.xCitations: 19Read the full textAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinked InRedditWechat Abstract Abstract: Patients with an autoimmune condition are known to be at higher risk of developing other autoimmune disorders. Type 1 diabetes may be associated with additional autoimmune disorders including autoimmune thyroid disease. The aim of this study was to investigate the prevalence of thyroid autoantibodies in a group of children, adolescents, and young adults with type 1 diabetes from northeastern Brazil as well as their significance for the development of thyroid disorders. The study design was cross-sectional and descriptive, analyzing young people with a previous type 1 diabetes diagnosis. Two hundred and fourteen children and adolescents with prior diagnosis of type 1 diabetes were evaluated. Antibodies to thyroperoxidase (anti-TPO) were determined in all patients and thyroid-stimulating hormone (TSH) levels. The anti-TPO antibody test was positive in 54 out of the 214 patients studied, resulting in an overall prevalence of 25.2%. Among the anti-TPO-positive subjects, females were predominant (72%) over males (28%) (p < 0.001). A total of 55.5% patients with positive anti-TPO antibodies had abnormal TSH levels. Clinically significant hypothyroidism was found in 29.6% and subclinical hypothyroidism in 22.2% of patients with positive anti-TPO. Hyperthyroidism was present in only 3% of them. Our results demonstrate the high prevalence of autoimmune thyroiditis in patients with type 1 diabetes and the need for these patients of regular screening to make a precocious diagnosis of thyroid dysfunction. Citing Literature Volume9, Issue4pt1August 2008Pages 272-276 RelatedInformation
Referência(s)