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Detection of Cytochrome P450 Substrates by Using a Small‐Molecule Droplet Array on an NADH‐Immobilized Solid Surface

2011; Wiley; Volume: 12; Issue: 18 Linguagem: Inglês

10.1002/cbic.201100541

1439-7633

Hiroshi Takayama, Shunji Takahashi, Takashi J. Moriya, Hiroyuki Osada, Yoshiharu Iwabuchi, Naoki Kanoh,

Microfluidic and Capillary Electrophoresis Applications

ChemBioChemVolume 12, Issue 18 p. 2748-2752 Communication Detection of Cytochrome P450 Substrates by Using a Small-Molecule Droplet Array on an NADH-Immobilized Solid Surface Correction(s) for this article Corrigendum: Detection of Cytochrome P450 Substrates by Using a Small-Molecule Droplet Array on an NADH-Immobilized Solid Surface Hiroshi Takayama, Shunji Takahashi, Takashi Moriya, Hiroyuki Osada, Yoshiharu Iwabuchi, Naoki Kanoh, Volume 12Issue 18ChemBioChem pages: 2715-2715 First Published online: December 9, 2011 Dr. Hiroshi Takayama, Dr. Hiroshi Takayama Graduate School of Pharmaceutical Sciences, Tohoku University, Sendai 980-8578 (Japan)Search for more papers by this authorDr. Shunji Takahashi, Dr. Shunji Takahashi Chemical Biology Core Facility, Chemical Biology Department, RIKEN Advanced Science Institute, 2–1 Hirosawa, Wako, Saitama 351-0198 (Japan)Search for more papers by this authorTakashi Moriya, Takashi Moriya Graduate School of Pharmaceutical Sciences, Tohoku University, Sendai 980-8578 (Japan)Search for more papers by this authorProf. Dr. Hiroyuki Osada, Prof. Dr. Hiroyuki Osada Chemical Biology Core Facility, Chemical Biology Department, RIKEN Advanced Science Institute, 2–1 Hirosawa, Wako, Saitama 351-0198 (Japan)Search for more papers by this authorProf. Dr. Yoshiharu Iwabuchi, Prof. Dr. Yoshiharu Iwabuchi Graduate School of Pharmaceutical Sciences, Tohoku University, Sendai 980-8578 (Japan)Search for more papers by this authorProf. Dr. Naoki Kanoh, Corresponding Author Prof. Dr. Naoki Kanoh nkanoh@m.tohoku.ac.jp Graduate School of Pharmaceutical Sciences, Tohoku University, Sendai 980-8578 (Japan)Graduate School of Pharmaceutical Sciences, Tohoku University, Sendai 980-8578 (Japan)Search for more papers by this author Dr. Hiroshi Takayama, Dr. Hiroshi Takayama Graduate School of Pharmaceutical Sciences, Tohoku University, Sendai 980-8578 (Japan)Search for more papers by this authorDr. Shunji Takahashi, Dr. Shunji Takahashi Chemical Biology Core Facility, Chemical Biology Department, RIKEN Advanced Science Institute, 2–1 Hirosawa, Wako, Saitama 351-0198 (Japan)Search for more papers by this authorTakashi Moriya, Takashi Moriya Graduate School of Pharmaceutical Sciences, Tohoku University, Sendai 980-8578 (Japan)Search for more papers by this authorProf. Dr. Hiroyuki Osada, Prof. Dr. Hiroyuki Osada Chemical Biology Core Facility, Chemical Biology Department, RIKEN Advanced Science Institute, 2–1 Hirosawa, Wako, Saitama 351-0198 (Japan)Search for more papers by this authorProf. Dr. Yoshiharu Iwabuchi, Prof. Dr. Yoshiharu Iwabuchi Graduate School of Pharmaceutical Sciences, Tohoku University, Sendai 980-8578 (Japan)Search for more papers by this authorProf. Dr. Naoki Kanoh, Corresponding Author Prof. Dr. Naoki Kanoh nkanoh@m.tohoku.ac.jp Graduate School of Pharmaceutical Sciences, Tohoku University, Sendai 980-8578 (Japan)Graduate School of Pharmaceutical Sciences, Tohoku University, Sendai 980-8578 (Japan)Search for more papers by this author First published: 07 November 2011 https://doi.org/10.1002/cbic.201100541Citations: 9Read the full textAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinked InRedditWechat Abstract Seeing below the surface: A small-molecule droplet array platform on an NADH-immobilized solid surface and a biotinylated acetophenone derivative were developed to identify the substrate candidates for soluble P450 enzymes of interest. This methodology is thought to be easily applicable to other class I P450 systems, including those that use NADPH as cofactor. Citing Literature Supporting Information Detailed facts of importance to specialist readers are published as "Supporting Information". Such documents are peer-reviewed, but not copy-edited or typeset. They are made available as submitted by the authors. Filename Description cbic_201100541_sm_miscellaneous_information.pdf2.4 MB miscellaneous_information Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article. Volume12, Issue18December 16, 2011Pages 2748-2752 RelatedInformation