Corticosterone Metabolism and the Incorporation of Leucine, Uridine, and Thymidine into Fetal Mouse Brain
1978; Springer Nature; Volume: 12; Issue: 12 Linguagem: Inglês
10.1203/00006450-197812000-00011
ISSN1530-0447
AutoresL. Tye, Nicole J. Michaud, A.F. Burton,
Tópico(s)Stress Responses and Cortisol
ResumoThe change in the pattern of biotransformation of [14C]corticosterone in fetal mouse brain between gestational day 14 and 17 increased the proportion of unchanged hormone from 9-75%. A sharp decrease in the in vitro incorporation of [14C]leucine, [3H]uridine, and [3H]thymidine into incubated brain coincided with this change and continued until day 19, when the incorporation of the 3 substrates had fallen to 9, 54, and 16%, respectively, of that on day 14. Injection of dexamethasone reduced values on day 14 to those normally found on days 15-18. Enzymes which metabolize corticosteroids regulate their activity in specific tissues; these data suggest a hormonal influence on developing brain.
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