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Is Inflammatory Bowel Disease a Risk Factor for Early Atherosclerosis?

2009; SAGE Publishing; Volume: 61; Issue: 2 Linguagem: Inglês

10.1177/0003319709333869

1940-1574

Necati Dağlı, Orhan Kürşat Poyrazoğlu, Adile Ferda Dağlı, Fatih Şahbaz, Ilgın Karaca, Mehmet Ali Kobat, Ibrahim Halil Bahçecıoğlu,

Systemic Lupus Erythematosus Research

Chronic inflammatory diseases are associated with an accelerated atherosclerotic process. Recent studies have discussed whether inflammatory bowel diseases (IBDs) can predict early atherosclerosis. We investigated this possibility.The study consisted of IBD cases (group 1, n = 40) and healthy persons (group 2, n = 40). The IBD group was selected so as not to have vascular disease or the presence of established major cardiovascular risk factors.Group 1 cases showed a significant increase in carotid intima media thickness (cIMT; P = .01). Carotid artery stiffness was impaired in group 1 (P = .03) and high-sensitivity C-reactive protein (hsCRP), homeostasis model assessment of insulin resistance (HOMA-IR), and homocysteine (Hyc) were higher in group 1 patients (P = .02, P = .03, P = .05).Inflammatory bowel disease patients have an increased risk of early atherosclerosis as shown by greater values of cIMT, carotid artery stiffness, Hyc, hsCRP, and insulin resistance.