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Association of SNAP-25 Gene Dde l and Mnl l Polymorphisms with Adult Attention Deficit Hyperactivity Disorder

2014; Korean Neuropsychiatric Association; Volume: 11; Issue: 4 Linguagem: Inglês

10.4306/pi.2014.11.4.476

1976-3026

Hasan Herken, Mehmet Emin Erdal, Ayşe Nur İnci Kenar, Gonca Ayşe Ünal, Burcu Çakaloz, Mustafa Ertan Ay, Erinç Yücel, Tuba Edgünlü, Cem Şengül,

Genetics and Neurodevelopmental Disorders

Objective The synaptosomal-associated protein of 25 kDa (SNAP-25) gene is a presynaptic plasma membrane protein and an integral component of the vesicle docking and fusion machinery mediating secretion of neurotransmitters. Previously, several studies reported association between SNAP-25 and attention deficit hyperactivity disorder (ADHD). We investigated whether these SNAP-25 polymorphisms (MnlI T/G and DdelI T/C) were also associated with ADHD in the Turkish population. Methods Our study comprised unrelated 139 subjects who met DSM-IV criteria for ADHD and 73 controls and all were of Turkish origin. Genetic analyses were performed and patients were evaluated with Wender-Utah Rating Scale and Adult ADD/ADHD DSM IV-Based Diagnostic Screening and Rating Scale. Results SNAP-25 DdelI polymorphism was not associated with ADHD but there was a statistically significant difference between ADHD patients and controls for SNAP-25 MnlI polymorphism. For SNAP-25 MnlI polymorphism patients with G/G genotype of the SNAP-25 gene MnlI polymorphism had higher Wender-Utah scores and higher scores in the 1st and 3rd parts of adult ADD/ADHD Scale. Conclusion We detected a significant association of the MnlI polymorphism in our ADHD sample which was similar to previous findings. Our study also revealed that SNAP-25 MnlI polymorphism was also associated with symptom severity of ADHD. This study is also, the first report on the association of SNAP-25 with ADHD in the Turkish population. Keywords: ADHD, SNAP-25 gene, Genetic