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Synaptic plasticity: hippocampal LTP

1995; Elsevier BV; Volume: 5; Issue: 3 Linguagem: Inglês

10.1016/0959-4388(95)80045-x

1873-6882

Alan U. Larkman, Julian Jack,

Neuroinflammation and Neurodegeneration Mechanisms

One of the most intensively studied forms of synaptic plasticity is long-term potentiation (LTP). The past year has seen further evidence advanced on both sides of the presynaptic/postsynaptic locus of expression debate, without an obvious path to reconcile the two views. Real progress has been made, however, in clarifying the possible role of nitric oxide as a retrograde messenger and the cellular location of its synthetic enzyme. Intriguing glimpses of the complex involvement of metabotropic glutamate receptors in the induction of LTP have also appeared.