Berninamycins B,C, and D, minor metabolites from Streptomyces bernensis.
1994; Springer Nature; Volume: 47; Issue: 12 Linguagem: Inglês
10.7164/antibiotics.47.1466
ISSN1881-1469
AutoresRaymond C. M. Lau, Kenneth L. Rinehart,
Tópico(s)Synthesis and Biological Activity
ResumoBerninamycins B, C, and D were isolated from fermentation of Streptomyces bernensis and their structures were studied with 13C NMR and FAB mass spectrometry. Berninamycin B has a valine unit in its cyclic peptide loop instead of the β-hydroxyvaline unit found in berninamycin A. Berninamycin D has two fewer dehydroalanine units attached to the carboxyl carbon of the pyridine ring. Based on FAB-MS results, berninamycin C is postulated to have only one dehydroalanine unit attached to the carboxyl carbon of pyridine. The biogenesis of berninamycins B, C, and D is discussed.
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