Editorial Revisado por pares

High-resolution mass spectrometry will dramatically change our drug-discovery bioanalysis procedures

2011; Future Science Ltd; Volume: 3; Issue: 11 Linguagem: Inglês

10.4155/bio.11.98

ISSN

1757-6199

Autores

Walter A. Korfmacher,

Tópico(s)

Metabolomics and Mass Spectrometry Studies

Resumo

BioanalysisVol. 3, No. 11 EditorialHigh-resolution mass spectrometry will dramatically change our drug-discovery bioanalysis proceduresWalter KorfmacherWalter KorfmacherPharmaceutical Consultant for Discovery BA, DMPK & MS Imaging, Westfield, NJ, USA. Published Online:7 Jun 2011https://doi.org/10.4155/bio.11.98AboutSectionsView ArticleView Full TextPDF/EPUB ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareShare onFacebookTwitterLinkedInRedditEmail View articleKeywords: drug discoveryhigh resolutionHRMSlead optimizationparadigm shiftqualitative/quantitativeSRMBibliography1 Korfmacher W. Bioanalytical assays in a drug discovery environment. In: Using Mass Spectrometry for Drug Metabolism Studies. Korfmacher W (Ed.). CRC Press, Boca Raton, FL, USA 1–34 (2005).Google Scholar2 Korfmacher WA. Principles and applications of LC–MS in new drug discovery. Drug Discov. Today10(20),1357–1367 (2005).Crossref, Medline, CAS, Google Scholar3 Korfmacher WA, Cox KA, Bryant MS, Veals J, Ng K, Lin CC. HPLC–API/MS/MS: a powerful tool for integrating drug metabolism into the drug discovery process. Drug Discov. Today2,532–537 (1997).Crossref, CAS, Google Scholar4 Yu K, Little D, Plumb R, Smith B. High-throughput quantification for a drug mixture in rat plasma – a comparison of ultra performance liquid chromatography/tandem mass spectrometry with high-performance liquid chromatography/tandem mass spectrometry. Rapid Commun. Mass Spectrom.20(4),544–552 (2006).Crossref, Medline, CAS, Google Scholar5 Wainhaus S. Fast chromatography with UPLC and other techniques. In: Using Mass Spectrometry for Drug Metabolism Studies (Second Edition). Korfmacher W (Ed.). CRC Press, Boca Raton, FL, USA 255–275 (2010).Google Scholar6 Wainhaus S, Nardo C, Anstatt R, Wang S, Dunn-Meynell K, Korfmacher W. 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Quantitative and confirmative performance of liquid chromatography coupled to high-resolution mass spectrometry compared with tandem mass spectrometry. Rapid Commun. Mass Spectrom.25(7),979–992 (2011).Crossref, Medline, CAS, Google Scholar11 Kerns E, Di L. Drug-like Properties: Concepts, Structure Design and Methods from ADME to Toxicity Optimization. Elsevier/Academic Press, NY, USA (2008).Google Scholar12 Zhang H, Ma L, He K, Zhu M. An algorithm for thorough background subtraction from high-resolution LC/MS data: application to the detection of troglitazone metabolites in rat plasma, bile, and urine. J. Mass Spectrom.43(9),1191–1200 (2008).Crossref, Medline, CAS, Google Scholar13 Zhu M, Ma L, Zhang D et al. Detection and characterization of metabolites in biological matrices using mass defect filtering of liquid chromatography/high resolution mass spectrometry data. Drug Metab. 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STAY CONNECTED Metrics Downloaded 1,037 times History Published online 7 June 2011 Published in print June 2011 Information© Future Science LtdKeywordsdrug discoveryhigh resolutionHRMSlead optimizationparadigm shiftqualitative/quantitativeSRMFinancial & competing interests disclosureThe author has no relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript. This includes employment, consultancies, honoraria, stock ownership or options, expert testimony, grants or patents received or pending, or royalties.No writing assistance was utilized in the production of this manuscript.PDF download

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