Produção Nacional
Revisado por pares
Pyrano chalcones and a flavone from Neoraputia magnifica and their Trypanosoma cruzi glycosomal glyceraldehyde-3-phosphate dehydrogenase-inhibitory activities
2000; Elsevier BV; Volume: 55; Issue: 6 Linguagem: Inglês
10.1016/s0031-9422(00)00248-x
ISSN1873-3700
AutoresDaniela M. Tomazela, Mônica Tallarico Pupo, Edna A. P. Passador, Maria Fátima das Graças Fernandes da Silva, Paulo C. Vieira, João B. Fernandes, Edson Rodrigues Fo, Glaucius Oliva, José Rubens Pirani,
Tópico(s)Natural product bioactivities and synthesis
ResumoThe fruits of Neoraptua magnifica var. magnifica afforded three new flavonoids: 2′-hydroxy-4,4′,-dimethoxy-5′,6′-(2″,2″-dimethylpyrano)chalcone, 2′-hydroxy-3,4,4′-trimethoxy-5′,6′-(2″,2″-dimethylpyrano)chalcone, and 3′,4′-methylenedioxy-5,7-dimethoxyflavone which were identified on the basis of spectroscopic methods. The known flavonoids 2′-hydroxy-3,4,4′,5-tetramethoxy-5′,6′-(2″,2″-dimethylpyrano)chalcone, 2′-hydroxy-3,4,4′,5,6′-pentamethoxychalcone, 3′,4′-methylenedioxy-5,6,7-trimethoxyflavone, 3′,4′-methylenedioxy-5′,5,6,7-tetramethoxyflavone, 3′,4′,5′,5,7-pentamethoxyflavanone and 3′,4′,5′,5,7-pentamethoxyflavone were also identified. The latter flavone was the most active as glyceraldehyde-3-phosphate dehydrogenase-inhibitor
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