Portal de Periódicos da CAPES

Intravenous morphine and nalbuphine increase histamine and catecholamine release without accompanying hemodynamic changes*

1995; Wiley; Volume: 58; Issue: 1 Linguagem: Inglês

10.1016/0009-9236(95)90075-6

1532-6535

Α. Doenicke, Jonathan Moss, W. Lorenz, R. Hoernecke,

Olfactory and Sensory Function Studies

Clinical Pharmacology & TherapeuticsVolume 58, Issue 1 p. 81-89 Pharmacodynamics and Drug Action Intravenous morphine and nalbuphine increase histamine and catecholamine release without accompanying hemodynamic changes Alfred Doenicke MD, Alfred Doenicke MD University of Munich, Munich, Germany University of Chicago, Chicago, Ill., USA Institute for Theoretical Surgery, Marburg, GermanySearch for more papers by this authorJonathan Moss MD, PhD, Corresponding Author Jonathan Moss MD, PhD University of Munich, Munich, Germany University of Chicago, Chicago, Ill., USA Institute for Theoretical Surgery, Marburg, GermanyJonathan Moss, MD, PhD, University of Chicago, Department of Anesthesia and Critical Care and Committee on Clinical Pharmacology, 5841 S. Maryland Ave., MC 4028, Chicago, IL 60637.Search for more papers by this authorWilfried Lorenz MD, Wilfried Lorenz MD University of Munich, Munich, Germany University of Chicago, Chicago, Ill., USA Institute for Theoretical Surgery, Marburg, GermanySearch for more papers by this authorRainer Hoernecke MD, Rainer Hoernecke MD University of Munich, Munich, Germany University of Chicago, Chicago, Ill., USA Institute for Theoretical Surgery, Marburg, GermanySearch for more papers by this author Alfred Doenicke MD, Alfred Doenicke MD University of Munich, Munich, Germany University of Chicago, Chicago, Ill., USA Institute for Theoretical Surgery, Marburg, GermanySearch for more papers by this authorJonathan Moss MD, PhD, Corresponding Author Jonathan Moss MD, PhD University of Munich, Munich, Germany University of Chicago, Chicago, Ill., USA Institute for Theoretical Surgery, Marburg, GermanyJonathan Moss, MD, PhD, University of Chicago, Department of Anesthesia and Critical Care and Committee on Clinical Pharmacology, 5841 S. Maryland Ave., MC 4028, Chicago, IL 60637.Search for more papers by this authorWilfried Lorenz MD, Wilfried Lorenz MD University of Munich, Munich, Germany University of Chicago, Chicago, Ill., USA Institute for Theoretical Surgery, Marburg, GermanySearch for more papers by this authorRainer Hoernecke MD, Rainer Hoernecke MD University of Munich, Munich, Germany University of Chicago, Chicago, Ill., USA Institute for Theoretical Surgery, Marburg, GermanySearch for more papers by this author First published: July 1995 https://doi.org/10.1016/0009-9236(95)90075-6Citations: 5AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Abstract Patients receiving intravenous morphine at doses of 0.3 and 1.0 mg/kg for general anesthesia have been reported to show significant elevations in plasma histamine that are associated with hemodynamic changes. We undertook a prospective, randomized, double-blind trial in which 0.15 mg/kg morphine or 0.3 mg/kg nalbuphine was administered intravenously to normal volunteers. Thirteen of 15 subjects receiving morphine and 10 of 14 subjects receiving nalbuphine had elevations in plasma histamine levels and symptoms of histamine release within 5 minutes of drug administration. Six subjects in the morphine group and five in the nalbuphine group exhibited levels of plasma histamine >2.0 ng/ml, but these levels were not associated with hemodynamic changes and occurred 10 to 15 minutes after drug administration. Our study suggests that the opiate-induced elevation of plasma histamine derives from cutaneous mast cells. Clinical Pharmacology & Therapeutics (1995) 58, 81–89; doi: 10.1016/0009-9236(95)90075-6 Citing Literature Volume58, Issue1July 1995Pages 81-89 RelatedInformation