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Artigo Acesso aberto Revisado por pares
BIBTEX RIS

Biocompatible Hydrogels by Oxime Click Chemistry

2012; American Chemical Society; Volume: 13; Issue: 10 Linguagem: Inglês

10.1021/bm301346e

ISSN

1526-4602

Autores

Gregory N. Grover, Jonathan Lam, Thi H. Nguyen, Tatiana Segura, Heather D. Maynard,

Tópico(s)

Click Chemistry and Applications

Resumo

Oxime Click chemistry was used to form hydrogels that support cell adhesion. Eight-armed aminooxy poly(ethylene glycol) (PEG) was mixed with glutaraldehyde to form oxime-linked hydrogels. The mechanical properties, gelation kinetics, and water swelling ratios were studied and found to be tunable. It was also shown that gels containing the integrin ligand arginine-glycine-aspartic acid (RGD) supported mesenchymal stem cell (MSC) incorporation. High cell viability and proliferation of the encapsulated cells demonstrated biocompatibility of the material.

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