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Ligand-Controlled, Tunable Silver-Catalyzed C–H Amination

2014; American Chemical Society; Volume: 136; Issue: 48 Linguagem: Inglês

10.1021/ja5094309

1943-2984

Juliet M. Alderson, Alicia M. Phelps, Ryan J. Scamp, Nicholas S. Dolan, Jennifer M. Schomaker,

Sulfur-Based Synthesis Techniques

The development of readily tunable and regioselective C-H functionalization reactions that operate solely through catalyst control remains a challenge in modern organic synthesis. Herein, we report that simple silver catalysts supported by common nitrogenated ligands can be used to tune a nitrene transfer reaction between two different types of C-H bonds. The results reported herein represent the first example of ligand-controlled and site-selective silver-promoted C-H amination.