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Water-Soluble Rhamnose-Coated Fe 3 O 4 Nanoparticles

2009; American Chemical Society; Volume: 11; Issue: 14 Linguagem: Inglês

10.1021/ol900949y

1523-7060

Lénaïc Lartigue, Khalid Oumzil, Yannick Guari≠, Joulia Larionova≠, Christian Guérin, Jean‐Louis Montero, Véronique Barragan-Montero, Claudio Sangregorio, Andréa Caneschi, Claudia Innocenti, T. Kalaivani, Paolo Arosio, A. Lascialfari,

Iron oxide chemistry and applications

Water-soluble biocompatible rhamnose-coated Fe3O4 nanoparticles of 4.0 nm are obtained by covalent anchorage of rhamnose on the nanoparticles surface via a phosphate linker. These nanoparticles present superparamagnetic behavior and nuclear relaxivities in the same order of magnitude as Endorem that make them potential magnetic resonance imaging (MRI) contrast agents of a second generation, where the saccharides represent also specific ligands able to target lectins on skin cells.