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Tetrahydrofuran Acetogenins from Laurencia glandulifera

2009; American Chemical Society; Volume: 72; Issue: 2 Linguagem: Inglês

10.1021/np800481w

1520-6025

Maria Kladi, Constantinos Vagias, Panagiota Papazafiri, Simone Brogi, Andrea Tafi, Vassilios Roussis,

Plant-derived Lignans Synthesis and Bioactivity

Five new C15 acetogenin en-ynes (1−5) with a rare tetrahydrofuran moiety and a linear biosynthetic precursor (6) were isolated from an organic extract of Laurencia glandulifera, collected from the island of Crete in the south Aegean Sea. The structures of the new natural products, as well as their relative configuration, were established by means of spectroscopic data analysis. The cytotoxicity of the isolated natural products was evaluated against five human tumor cell lines.