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Inhibition of rabbit reticulocyte protein kinases by hemin

1976; Elsevier BV; Volume: 71; Issue: 4 Linguagem: Inglês

10.1016/0006-291x(76)90744-0

1090-2104

James D. Hirsch, Orlando J. Martelo,

Porphyrin Metabolism and Disorders

Hemin, at concentrations optimal for globin synthesis, produces inhibition of a specific cytoplasmic protein kinase and a ribosome-associated protein kinase isolated from rabbit reticulocytes. Both enzymes are cyclic AMP-dependent. This inhibition is noncompetitive and greater when ribosomal proteins are used as the phosphate acceptors. The inhibition of these protein kinases by hemin and its partial reversal by globin suggests that hemin regulates protein kinase activity in reticulocytes.