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Coexistent chronic myelocytic leukemia, monoclonal gammopathy and multiple chromosomal abnormalities

1966; Elsevier BV; Volume: 41; Issue: 6 Linguagem: Inglês

10.1016/0002-9343(66)90055-6

1555-7162

Stephan E. Ritzmann, Earl J. Stoufflet, Elsie W. Houston, William C. Levin,

Immunodeficiency and Autoimmune Disorders

M ONOCLONAL gammopathy [ 7,2], usually associated with myeloma and primary macroglobulinemia (WaldenstrGm), has also been reported in association with a variety of myeloproliferative disorders, including polycythemia [&9], myelofibrosis [3,8,9], myelofibrosis with myeloid metaplasia (31, osteomyelosclerosis [Will, erythremic myelosis [ 721, erythroleukemia [73], acute myeloblastic or lymphoblastic leukemia [7] and chronic myelocytic leukemia [74-791. Dittmar et al. have reported a biclonal gammopathy in association with polycythemia [20]. We have observed in an adult male subject the coincidence of chronic myelocytic leukemia, monoclonal gammopathy (IgG, type K) and chromosomal abnormalities characterized by several stem lines, one of which exhibited both the Phr chromosome and a chromosomal aberration heretofore observed to be associated with primary macroglobulinemia (WaldenstrBm).