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Artigo Acesso aberto Revisado por pares
BIBTEX RIS

357 Tolerance to piroxican in patients with urticaria to NSAIDs

1991; Elsevier BV; Volume: 87; Issue: 1 Linguagem: Inglês

10.1016/0091-6749(91)91640-f

ISSN

1097-6825

Autores

Ariel Ceriotto Garcia, María José Carmona, M. Blanca, Josep M. De Vega, Andreza Monforte Miranda, Jorge García‐García, Manuela Jorquera, Francisco Burgos, M PEREZESTRADA,

Tópico(s)

Autoimmune Bullous Skin Diseases

Resumo

Plroxican (PI) is a prostaglandln inhibitor compound with a low incidence of reported adverse effects.Better tolerance than indomethacin, naproren and ASA has been reported'.Since urtlcarla and anaphylactic shock can be produced by different NSAID compounds not chemically related possibly interact@ in a common mechanism with the synthesis and release of inflammatory mediators, this drug has the potential to induce such reactions in cases of intolerance to other NSAIDS.'Ike tolerance to PI is studied in a group of patients with intolerance to NSAlDs compounds.All the patients reporting to our outpatient clinic referred as allergic to diGrent NSAlDs entered a protocol for establishing the tolerance to PI.In order to assess tolerance to several NSAIDs a single blind challenge was made giving the following drugs: paracctamol (500 me) mefenamic (250 mef, indomethacin (25 mg), dipirone (500 mg), ASA (500 mg), ketoprofen (100 utg) and placebo.When the patients were allergic to only one drug and tolerated the remaining NSAlDs, they were not included in the study.25 patients were studied: 18 proved to be allergic to several drugs and only 7 to one.In the group of 18 NSAID positive, 12 reported problems with at least 2 different NSAlDs and 6 with only ASA.After administering PI 5 cases developed urticaria atter 20 mg and 1 atter 5 mg. 12 eases tolerated the drug.This represents 33 % of cross-reactivity, According to these data in cases of intolerance to NSAlDs the administration of PI can produce the reactions in a high percentage of cases.Thus tolerance to this drug needs to be established before administration in cases of NSAID idiosyncrasy.1.

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