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Viral Loads in Clinical Specimens and SARS Manifestations

2004; Centers for Disease Control and Prevention; Volume: 10; Issue: 9 Linguagem: Inglês

10.3201/eid1009.040058

1080-6059

Ivan Fan‐Ngai Hung, Vincent Chi‐Chung Cheng, Alan Wu, Bone S. F. Tang, Kwok Hung Chan, Chung‐Ming Chu, Maureen Mo-Lin Wong, W.T. Hui, Leo L. M. Poon, Doris M. W. Tse, KH Chan, Patrick C. Y. Woo, Susanna K. P. Lau, Malik Peiris, Kwok‐Yung Yuen,

SARS-CoV-2 detection and testing

Abstract A retrospective viral load study was performed on clinical specimens from154 patients with laboratory-confirmed severe acute respiratory syndrome (SARS), prospectively collected during patients’ illness. Viral load in nasopharyngeal aspirates (n = 142) from day 10 to day 15 after onset of symptoms was associated with oxygen desaturation, mechanical ventilation, diarrhea, hepatic dysfunction, and death. Serum viral load (n = 53) was associated with oxygen desaturation, mechanical ventilation, and death. Stool viral load (n = 94) was associated with diarrhea, and urine viral load (n = 111) was associated with abnormal urinalysis results. Viral replications at different sites are important in the pathogenesis of clinical and laboratory abnormalities of SARS.