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Application of differential scanning calorimetry to the study of drug-excipient compatibility

1996; Elsevier BV; Volume: 285; Issue: 2 Linguagem: Inglês

10.1016/0040-6031(96)02904-8

1872-762X

Fabrizio Balestrieri, Andrea Magrì, Antonio Magrı̀, Domenico Marini, Amalia Sacchini,

Analytical Chemistry and Chromatography

Differential scanning calorimetry (DSC) has been used to investigate drug-excipient interactions and, in consequence, their compatibility. In particular, binary mixtures of nefazodone with magnesium stearate and lactose, and fosinopril with the same excipients were prepared and analysed, after proper conditioning. The thermoanalytical results were compared with those obtained by spectroscopic (UV, IR) and chromatographic (HPLC) analysis. We believe that changes in DSC runs cannot always be a sufficient condition to prove that some interaction occurs between drug and excipient during storage at room temperature. Some data on the spectroscopic characteristics of nefazodone and fosinopril drugs and their thermal behaviour are also reported.